Solomonic learning: Large language models and the art of induction

Large language models’ emergent abilities are improving with scale; as scale grows, where are LLMs heading? Insights from Ray Solomonoff’s theory of induction and stochastic realization theory may help us envision — and guide — the limits of scaling.

“One year of research in neural networks is sufficient to believe in God.” The writing on the wall of John Hopfield’s lab at Caltech made no sense to me in 1992. Three decades later, and after years of building large language models, I see its sense if one replaces sufficiency with necessity: understanding neural networks as we teach them today requires believing in an immanent entity.

Stefano Soatto.png
Stefano Soatto, a vice president and distinguished scientist with Amazon Web Services.
Credit: UCLA Samueli

Let’s start from the basics: when we teach machine learning, we say that memorization is bad, because it leads to overfitting and prevents generalization. Generalization is good — so good that, to achieve it, we incentivize machines not to memorize, through “regularization”. We even prove theorems — so-called uniform generalization bounds — that guarantee generalization no matter what distribution the data are drawn from, provided we avoid memorization.

But my mother always told me not to generalize, and she had me commit to memory countless useless poems in elementary school. Why am I teaching that generalization is good and memorization is bad, when I was taught the opposite?

Biology vs. technology

Machine learning has historically drawn inspiration from biology. But biological systems have hard ontogenic and phylogenic memory bounds: our synapses cannot memorize everything we experience, and our DNA cannot transmit the knowledge we’ve accumulated to our descendants. (As an educator and father, I often wished I could upload what I have learned into my students and kids. I haven’t figured that one out, but can we at least do it for AI models?) Furthermore, biology imposes a strong evolutionary bias toward minimizing inference latency: when facing an animal in the wild and having to determine who’s whose meal, we can’t reason through all past memories lest the decision be made for us.

In other words, biological systems are forced to adopt inductive learning, using specific data from the past (or a “training set”) to devise a process for handling any future data. Success in inference from inductive learning (or more simply, induction) relies on the so-called inductive hypothesis, that past performance can guarantee future rewards (the primate species called “financial advisor” has evolved out of this belief).

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Technology does not have the limitations of biological systems: there are no hard memory bounds (we can always add more storage) and no hard computational bounds (we can fire up more computers), at least until we hit cosmic limits. If we accept that machines do not have the same limitations as biology, what is the best inference paradigm for them? That is, given a training set and a test query, how can they devise the best answer?[1] If we want our model to operate in the constantly evolving real world, we shouldn’t assume the existence of a single distribution from which all data are drawn, in principio, nunc, et semper.

Inference that allows processing the training data at inference time is called transductive inference, or transduction. Transduction calls for us to memorize and reason, unlike induction, which wants us to generalize and forget. To perform optimal inference with respect to any hypothetical distribution in the future, one must memorize past data and, only when presented with a specific query, deploy “reasoning” skills and access memory to compute the best possible answer to that query.

Induction calls for forgetting what does not matter during training, under the assumption that the training set is representative of all future data. But in reality, one cannot know what data will be useful when, so memorization is wise if one can afford it, even when the data — like the writing on John Hopfield’s lab’s wall — does not make sense in that moment.

Transductive inference from inductive learning

Uniform generalization bounds may seem powerful because they are valid for any distribution; but for them to work, there can be only one distribution from which both past and future data are independently sampled. Paraphrasing the statistician Bruno de Finetti, this distribution does not exist in any objective or material sense. It is an abstract concept, the product of our imagination. Something we concoct to guide our intuition and analysis.

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The inductive hypothesis is fundamentally not verifiable: any finite training data could have been drawn with identical likelihood from infinitely many distributions, so even if there was a single true one, how would we know which? Once the present is past, we cannot repeat the experiment. The inductive hypothesis is a statement of faith and uniform generalization bounds an expression of hope, not quite within the scientific realm.

Don’t get me wrong: hope can pay off. The future often does resemble the past. But many of the mechanisms that generate the data we care about today, in business, finance, climate, and language, evolve over time. The same word can carry a different meaning today than it did a century, or even a decade, ago. The point is that whether the inductive hypothesis holds or not cannot be known ahead of time.

Solomonoff inference

What if we forgo generalization and embrace memorization and reasoning? Is that what LLMs are doing? If so, where are they heading? What does the limit of optimal transductive inference look like?

The answer was given in 1964 by the mathematician Ray Solomonoff and is now known, somewhat confusingly, as Solomonoff induction. I will refer to it as Solomonoff inference, which can be thought of as the limit of scaling laws when we allow memory, computational capacity, and time to grow to infinity.

Solomonoff inference is optimal with respect to all computable distributions, averaged with respect to the universal prior. The Church-Turing thesis predicates that any physically realizable mechanism belongs to this class. While infeasible in practice, since it requires infinite resources, Solomonoff’s algorithm is quite simple: execute all programs in increasing order of length until one manages to spit out all the data observed up to now, bit by bit, if it terminates.

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The optimal algorithm is basically a lookup table with a switch. There is no insight, no knowledge, not even learning. If presented with the same query twice in a row, the optimal algorithm would repeat the same procedure all over, having learned nothing from past experience.

Solomonoff inference is quite unlike neural networks, which are trained by comparing gradient vectors in a high-dimensional space, where the data are embedded. But could it be that, as we scale LLMs to larger and larger sizes, their behavior is beginning to resemble Solomonoff inference? After all, LLMs are known to memorize, albeit imperfectly, and they can perform universal computation, at least if augmented with a scratchpad. Indeed, LLMs are already able to perform rudimentary transductive inference, now known as “in-context learning” — somewhat confusingly, as it involves no learning: if presented with the same context twice, an LLM would repeat the same process, with no improvement from experience.

So, if LLMs were to begin to perform Solomonoff inference, would they become “superintelligent”? Given no accepted definition of intelligence, let alone its superlatives, many tacitly assume inference performance as its proxy: “smarter” models (or students) perform better on tests, whether the SAT, GRE, or BAR, or the famed IMO math competition. The higher the score, the more “intelligent” the model must be! But the absolute best would be Solomonoff’s algorithm, and no matter what one’s definition of intelligence is, Solomonoff’s algorithm cannot meet it: if by mistake the IMO printed each question twice, Solomonoff’s algorithm would redo the same work twice, not exactly what most would call “intelligent” behavior.

As an analogy, an “inductive student” is a diligent pupil who studies the textbook and completes all homework assignments and practice problems before showing up at the exam. So long as the questions are close enough to practice problems, the inductive student does well. On the occasional odd (or out-of-distribution, as a believer in induction would say) question, the inductive student may not do as well.

By contrast, the “transductive student” does not study at all and instead shows up at the exam with the textbook in hand. Only after reading the first question does the transductive student go through the book to find all the pieces needed to assemble an answer. The student could, in principle, repeat the exercise all the way to the last question, learning nothing in the process. As Solomonoff showed us, there is no need to be smart if one has unbounded time, memory, and computational power.

Do we want models that perform well on benchmark exams, or is the kind of “intelligence” we want something else? Fortunately, inductive and transductive inference are not mutually exclusive. In fact, their difference is quite subtle, as one could frame either as a special case of the other, and the two coincide when the data are independently and identically distributed.

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What matters is that LLMs are inductively trained transductive-inference engines and can therefore support both forms of inference.[2] They are capable of performing inference by inductive learning, like any trained classifier, akin to Daniel Kahneman’s “system 1” behavior — the fast thinking of his book title Thinking Fast and Slow. But LLMs are also capable of rudimentary forms of transduction, such as in-context-learning and chain of thought, which we may call system 2 — slow-thinking — behavior. The more sophisticated among us have even taught LLMs to do deduction — the ultimate test for their emergent abilities.

AI models’ inferential abilities are improving organically with scale — although they’re still inferior to those of the best humans on most tasks. But they are also being actively fostered through the use of formal-verification tools such as LEAN, as is happening at AWS. One could call this paradigm Solomonic learning: embrace memorization and foster reasoning, yet do not eschew induction. Simple tasks that might benefit from past experience can be solved inductively, saving time and energy, but doing so requires “understanding” and “insight”.

Given that paradigm, the question is what classes of models best support Solomonic learning.

Architectures for Solomonic learning

Solomonic learning requires models that can memorize and perform computation at inference time, in addition to performing ordinary induction. The model architectures therefore need eidetic (verbatim) working memory, which could fade over time, to support computation; but they also need long-term memory to easily retrieve facts from the distant past (the purpose for which humans invented the printing press).

To adapt to changing conditions, they need their long-term memory to decay in synchrony with changes to the mechanisms that generate the data they process. Evolution does that for biological agents, to the benefit of the species rather than any one individual. Transformers, the workhorses of current LLMs, have eidetic (verbatim) memory “in context”, but only until tokens slide out of context. They also have permanent memory “in weights”, but training data are not accessible eidetically from the weights, and there is no long-term adaptation. Eidetic long-term memory can be accessed through RAG (retrieval-augmented generation), but in current Transformers, RAG is not integrated into the primary (autoregressive) inference loop.

Stochastic realization theory and input-dependent state space models

Half a century ago, stochastic realization theory tackled the question of how to model sequential data for downstream decision or control tasks. The “state” of the model was defined as the function of past data that is sufficient for the future, meaning that, given the state, one can discard all past data and predict future data as well as if the data had been retained.

The trivial state is the data itself. An optimal state, by definition, supports an optimal predictor, which is one that makes the prediction error unpredictable. Then, by construction, the state contains all the “information” in past data. During training, the states of LLMs are their weights, so it should be no surprise that next-token prediction is the method of choice for training them. During inference, the state of a Transformer-based LLM is the sliding window of tokens, which is “deadbeat”, meaning that it decays to zero in finite steps without a driving input.

B'MOJO.jpg
In B’MOJO, a state-space model (SSM) computes a fading memory that represents long-range dependencies through a fixed-dimensional representation (pink). The eidetic memory, by contrast, selects tokens from the past (dark-blue x's) using an innovation test over the SSM output and appends them to the current sliding window. Adapted from "B'MOJO: Hybrid state space realizations of foundation models with eidetic and fading memory".

In general, as we observe more and more data during both training and inference, the state must grow apace. In the 1970s, an unbounded state was unthinkable, so the key question was how to find a fixed-dimensional state that is optimal even as the data volume grows to infinity. Therefore, stochastic realization theory focused on Markov processes that admit a finite-dimensional state.

Since any finite-memory sequence could be modeled as the output of a linear model driven by white zero-mean Gaussian noise, the attention was all on linear state-space models (SSMs). While simplistic, such SSMs were good enough to take us to the moon. Today, an unbounded state is not unthinkable. Nonetheless, LLM weights are fixed after training, and the context size is imposed by hardware limitations. So we need richer architecture families.

As an aside, I wish to stress the distinction between the model, which is any state-space realization that supports optimal prediction (there are generally infinitely many), and the system, which is the “real” mechanism that generates the data. The system is unknown and unknowable; the model is tangible and entirely under our control. Although as engineers we are trained to believe that models of the world converge to the “true” system as they improve, this position — known in epistemology as "naïve realism" — is scientifically indefensible.[3]

Amazon’s Stefano Soatto on how learning representations came to dominate machine learning.

To stress the dichotomy between the system and the model, in 1979, Anders Lindqvist and Giorgio Picci derived an equation that, four decades later, is at the heart of diffusion models. In a dissipative physical system, time cannot be reversed, bu it can in a model of that system, for instance a Gaussian SSM. The structure of the reverse diffusion in the model is the same as the forward diffusion, a fact that is exploited in diffusion models for image generation.[4]

Unlike deadbeat Transformers, SSMs have unbounded memory, but it fades, making them incompatible with optimal transductive inference. Again in the 1970s, the late Roger Brockett triggered a burst of interest in input-dependent state-space models, where some of the parameters are affected by the input, the simplest case being when they interact (bi-)linearly with the state. Art Krener showed that such bilinear SSMs can approximate an arbitrarily complex nonlinear (smooth) model. Alberto Isidori and coworkers extended stochastic realization theory to bilinear models, but still with an eye to making the state as small as possible.

Even 30 years later, prior to the deep-learning revolution, when we used input-dependent SSMs to generate videos of dynamic textures, we were still focused on keeping the state dimension as small as possible, encouraged by the fact that 20 states were sufficient to animate and control the rendering of waterfalls, flames, smoke, foliage, talking faces, and other stationary processes. Thanks to the reversibility of the model, we could even make smoke or steam move faster, slower, or backwards!

Deep learning twisted Occam’s razor by trying to make the embedding dimension of the training state (the weights) as large as possible, not as small as possible. Dimension is only an upper bound on “information,” and the key to induction is to limit the “information” in, not the dimension of, the trained weights.[5] Two decades later, we stacked SSMs into a neural architecture by feeding the (input-dependent) prediction residual of one layer to the next.

A breakthrough came with Mamba, which showed that efficient implementation at the hardware level is key. When Mamba is stripped down (as it is in appendix E of our recent paper on architectures to support transductive inference), it is a stack of bilinear SSMs (which Mamba’s developers call “selective state-space models”) restricted to non-interacting states (diagonal dynamics), so it can be implemented efficiently in hardware.

Diagonal SSMs are disjoint from and complementary to Transformers. Autoregressive (AR) Transformers have nilpotent dynamics, meaning that the state transition matrix becomes zero in a finite number of steps in the absence of external input. Mamba has diagonal dynamics, and nilpotent matrices cannot be diagonalized. Diagonal SSMs support infinite fading memory; AR Transformers support finite eidetic memory, and neither is general. Instead, any general (bi-)linear system can be converted to a so-called canonical form, also derived in the 1970s, which can support both eidetic and fading memory.

Meet B’MOJO

B’MOJO is a family of architectures based on canonical realizations that include Transformers, Mamba-like SSMs, and any hybrid combination of the two. There are combinatorially many options, and the name of the game is to find those that are sufficiently general to support different memory regimes yet can be efficiently mapped to specific hardware in order to scale. We plan to release basic versions of B’MOJO both for GPU hardware and for Amazon’s Trainium hardware, so they can be easily compared with existing Transformers, SSMs, and hybrid architectures.

The writing on the wall

While a representation of the “true” system is fundamentally elusive, lending credence to the writing on the wall of John Hopfield’s lab back in 1992, building model realizations is a concrete exercise grounded in data. LLMs, where the “L” refers not to natural language but to the inner language that emerges in the trained model at scale, are stochastic realizations trained inductively as optimal predictors and coopted for (suboptimal) transductive inference and generation. If the training data subtend latent logical structures, as do sensory data such as visual or acoustic data, models trained as optimal predictors are forced to capture their statistical structure.

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Thus, LLMs in our parlance include so-called world models trained with visual, acoustic, olfactory, tactile, and other sensory data. The model is indifferent to whether tokenized data express some abstract concept in natural language or a physical measurement process in finite precision. The resulting LLMs can represent concepts and meanings, including physical concepts such as the laws of physics, and can in principle reason, although at present they appear to be mostly building ever bigger lookup tables. Regardless, as stochastic dynamical models, LLMs can be controlled, probed with causal interventions, made observable, and studied with the tools of dynamical-systems theory.

A model is an abstraction of the underlying world — not a representation of it, because there is no objective “it” to re-present, but a realization of it, made real through the only objective entity, which is the data. Synthetic data are just as real to the model as data produced by a physical measurement process, and aligning the two is the essence of perception, for this reason often referred to as controlled hallucination.

While much of the popular discourse denigrates hallucinations[6] as something to be avoided, the ability to hallucinate is necessary for reasoning. The question is not how to avoid hallucinations but how to control them, which is the process of alignment. Architectures designed for decision and control can help, and decades of work in dynamical systems and controls may provide insights — hopefully without the need to resort to divinity, as the writing on the wall suggested.

Footnotes

[1] Note that "best" does not mean "correct." If the data is insufficient to identify the correct conclusion, even the best answer can be wrong.

[2] The simplest form of inductive learning for transductive inference is transductive fine-tuning, a form of meta-learning: past data is used to "meta-train" a model that, at inference time, is fine-tuned with a small number of examples ("few shots") to perform a new task. LLMs take this program steps further, by using sequential data with a latent logical structure (not only natural language but also video, audio, and other signals) to produce an “inner language” (we call it "Neuralese") that can then be co-opted for transductive inference.

[3] Quoting Bertrand Russell: “We all start from 'naïve realism,' i.e., the doctrine that things are what they seem. ... The observer, when he seems to himself to be observing a stone, is really, if physics is to be believed, observing the effects of the stone upon himself. Thus science seems to be at war with itself: when it most means to be objective, it finds itself plunged into subjectivity against its will. Naïve realism leads to physics, and physics, if true, shows that naïve realism is false. Therefore naïve realism, if true, is false; therefore it is false.” Even the International Vocabulary of Metrology has dispensed with the notion of “true value” in its most recent revisions.

[4] In the paper that introduced diffusion models for image generation, the reverse-diffusion equation was attributed to a 1949 work of Feller. However, forward diffusion in the form in use today was not derived until 1960, so neither was reverse diffusion. Later references attribute the reverse-diffusion equation to a 1982 paper by B. D. O. Anderson, which, however, did not introduce it but instead described it, based on the 1979 paper of Lindqvist and Picci, correctly referenced in Anderson’s work, and extended it to more general models different from those in use in diffusion models today. The correct reference for the reverse-diffusion equation used in diffusion models is therefore Lindqvist-Picci 1979.

[5] I use quotes because defining information for the weights of a trained model entails some subtleties, but it can be done.

[6] "Hallucinations" are data generated by a model that are statistically compatible with the training set (in the sense of high likelihood under the trained model), yet "wrong", i.e., individually inconsistent with constraints that some external oracle has deemed "true" ("facts", or "axioms"). In other words, hallucinations are the product of any generative model. Outside formalized domains such as math or code, there is no objective "truth", so the oracle is replaced by an accepted knowledge base, which depends on the application. For "common sense" knowledge, the base is generally a large corpus of (more or less) verified facts, such as WikiData. Outside formalized domains, including the law, there is no guarantee that the facts or "axioms" are mutually compatible.

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You will design, build, and continuously improve the forecasting and optimization models that ensure the right compute, storage, and networking resources are available at the right time, in the right regions, at the lowest possible cost, without ever compromising the end user experience. This is a high impact individual contributor role for someone who thrives at the intersection of applied research and production systems. You will define the scientific roadmap for capacity intelligence, turning reactive provisioning into a predictive, self optimizing engine that anticipates demand before customers feel any constraint. Key job responsibilities Define and drive the scientific strategy for capacity modelling, establishing the research agenda that transforms how WorkSpaces forecasts demand, plans supply, and allocates resources across a globally distributed infrastructure. Build advanced demand forecasting models that predict workspace usage across multiple time horizons, from intraday spikes to long range growth trajectories, incorporating signals such as customer onboarding patterns, seasonal trends, regional expansion, and macroeconomic indicators. Design supply optimization frameworks that determine optimal resource placement, instance mix, and pre warming strategies, balancing availability, performance, and cost by reasoning over hardware constraints, pricing dynamics, and service level objectives. Develop causal and probabilistic models that move beyond trend extrapolation to true understanding of demand drivers, enabling the organization to distinguish organic growth from one time events, anticipate shifts in usage patterns, and quantify uncertainty in planning decisions. Architect simulation and scenario planning systems that allow business and engineering leaders to run what if analyses, stress test capacity plans against disruption scenarios, and evaluate trade offs between investment timing, risk tolerance, and customer experience. Pioneer the integration of machine learning with operations research, combining deep learning based forecasting with mathematical optimization to jointly solve the demand prediction and resource allocation problem in a way that neither discipline can achieve alone. Establish evaluation frameworks and monitoring systems that measure forecast accuracy, capacity utilization, and cost efficiency in production, creating tight feedback loops that drive continuous model improvement and build organizational trust in science driven planning. Influence the broader organization's capacity strategy by translating model outputs into actionable recommendations for leadership, identifying opportunities to extend capacity intelligence patterns to adjacent services, and mentoring scientists and engineers across the team. About the team As part of the AWS solutions organization, we have a vision to provide business applications, leveraging Amazon's unique experience and expertise, that are used by millions of companies worldwide to manage day-to-day operations. We will accomplish this by accelerating our customers' businesses through delivery of intuitive and differentiated technology solutions that solve enduring business challenges. we blend vision with curiosity and Amazon's real-world experience to build opinionated, turnkey solutions. Where customers prefer to buy over build, we become their trusted partner with solutions that are no-brainers to buy and easy to use. Diverse Experiences AWS values diverse experiences. Even if you do not meet all of the preferred qualifications and skills listed in the job description, we encourage candidates to apply. If your career is just starting, hasn’t followed a traditional path, or includes alternative experiences, don’t let it stop you from applying. Why AWS? Amazon Web Services (AWS) is the world’s most comprehensive and broadly adopted cloud platform. We pioneered cloud computing and never stopped innovating — that’s why customers from the most successful startups to Global 500 companies trust our robust suite of products and services to power their businesses. Inclusive Team Culture AWS values curiosity and connection. Our employee-led and company-sponsored affinity groups promote inclusion and empower our people to take pride in what makes us unique. Our inclusion events foster stronger, more collaborative teams. Our continual innovation is fueled by the bold ideas, fresh perspectives, and passionate voices our teams bring to everything we do. Mentorship & Career Growth We’re continuously raising our performance bar as we strive to become Earth’s Best Employer. That’s why you’ll find endless knowledge-sharing, mentorship and other career-advancing resources here to help you develop into a better-rounded professional. Work/Life Balance We value work-life harmony. Achieving success at work should never come at the expense of sacrifices at home, which is why we strive for flexibility as part of our working culture. When we feel supported in the workplace and at home, there’s nothing we can’t achieve.
GB, London
In Amazon Advertising, we apply machine learning at massive scale to optimize the prediction, ranking, and bidding behind every ad — deciding, in milliseconds, which ads to show shoppers and how to value them. We're looking for an Applied Scientist to help make sure the ads shoppers see are the right ones for them. You'll work across the science of how we rank, value, and bid on ads for Amazon DSP (Amazon's Demand-Side Platform) — including how we judge whether an ad is a good fit for the page a shopper is on and for the shopper themselves. It's high-scale, low-latency, customer-facing science: your models run live in front of millions of shoppers under tight real-time constraints. The questions are genuinely open — how do you tell whether an ad is relevant to someone, how do you balance what's good for shoppers, advertisers, and Amazon, and how do you keep getting that right as shopping behavior and inventory shift underneath you? Your work will have real impact, and you'll have room to shape where we take it. A few things make this stand out: your models touch a huge share of the ads shoppers see every day, so even small improvements add up fast; you'll run modern ML live under strict latency limits, across regions and very different types of ad inventory; and the problem space is rich — from how we value and bid on ads, to keeping models stable as traffic shifts, to what makes an ad a good fit for a shopper. Key job responsibilities - Design and improve the models that decide how ads are ranked, valued, and priced — including how relevant an ad is to the page and the shopper. - Apply and extend state-of-the-art techniques across e.g. ranking, deep learning, and information retrieval. - Own problems end to end: frame them, prototype, experiment, and ship them to production. - Balance competing objectives — shopper experience, advertiser and publisher value, and Amazon's business — into models that hold up across placements and marketplaces. - Communicate your work clearly to both business and science audiences, tailoring how you share it to each. - Write and ship your own production code backed by strong engineering support — we're all builders here. - Move fast with the best tools available, including modern AI coding assistants and agents. A day in the life You might start by digging into last week's experiment results, then use an AI coding agent to get your next prototype built and ready to test in production. In the afternoon you could be sketching a new way to measure ad relevance, reading a recent paper that bears on it, and talking it through with a senior scientist on the team. You'll move between hands-on science, writing and shipping real production code, and making the calls on your own work. About the team We're a group of scientists and engineers based in Edinburgh and London, working to make Amazon's ads more performant and relevant. We sit within a larger team spread primarily across New York City and the UK, and we have a broad mandate to build and experiment. You'll work alongside senior applied scientists you can learn from, with the data and infrastructure to do the work well and room to grow — with opportunities to attend top conferences (e.g., NeurIPS, KDD, ICML) and take on more scope over time.
IN, HR, Gurugram
Work on ML teams building large-scale forecasting and optimization systems that power Amazon’s global transportation network and directly impact customer experience and cost. As an Applied Scientist II, you will set scientific direction, mentor applied scientists, and partner with engineering and product leaders to deliver production-grade ML solutions at massive scale. Key job responsibilities 1. Lead and grow a high-performing team of Applied Scientists, providing technical guidance, mentorship, and career development. 2. Define and own the scientific vision and roadmap for ML solutions powering large-scale transportation planning and execution. 3. Guide model and system design across a range of techniques, including tree-based models, deep learning (LSTMs, transformers), LLMs, and reinforcement learning. 4. Ensure models are production-ready, scalable, and robust through close partnership with stakeholders. Partner with Product, Operations, and Engineering leaders to enable proactive decision-making and corrective actions. 5. Own end-to-end business metrics, directly influencing customer experience, cost optimization, and network reliability. 6. Help contribute to the broader ML community through publications, conference submissions, and internal knowledge sharing. A day in the life Your day includes reviewing model performance and business metrics, guiding technical design and experimentation, mentoring scientists, and driving roadmap execution. You’ll balance near-term delivery with long-term innovation while ensuring solutions are robust, interpretable, and scalable. Ultimately, your work helps improve delivery reliability, reduce costs, and enhance the customer experience at massive scale.
US, WA, Seattle
As part of the AWS Applied AI Solutions organization, we have a vision to provide end user applications, leveraging Amazon's unique experience and expertise, that are used by millions of companies worldwide to manage day-to-day operations. We will accomplish this by accelerating our customers' businesses through delivery of intuitive and differentiated technology solutions that solve enduring business challenges. We blend vision with curiosity and Amazon's real-world experience to build opinionated, turnkey solutions. Where customers prefer to buy over build, we become their trusted partner with solutions that are easy to adopt and easy to use. The Team Join the next science revolution at AWS Life Sciences Applied AI Solutions, where you'll work alongside world-class scientists to build AI that transforms how therapeutics are discovered, developed, and brought to patients. We're out to revolutionize how medicines are discovered, developed, and brought to patients, powered by a new generation of AI. Our team tackles some of the hardest open problems at the intersection of frontier AI and life sciences. We apply biological foundation models, large language models, and agentic reasoning systems to life sciences problems, then put them into the hands of pharma, biotech, and diagnostics customers as applications and managed services they can fine-tune, tailor, and deploy on their own data. The science challenges are deep: how do you design agentic systems that reason correctly over complex biological, regulatory, and clinical logic? How do you enable customers to tailor foundation models to their proprietary data and get better outputs with less effort? How do you adapt models to reason faithfully in high-stakes scientific and regulatory domains? Today we're focused on two areas. In drug design, our products (including Amazon Bio Discovery) accelerate discovery by giving bench scientists AI-guided protein engineering and antibody design capabilities. In clinical trials, we're building AI that automates and optimizes regulatory and clinical development workflows. We combine frontier research with production-scale delivery to put breakthrough science into the hands of customers solving humanity's hardest problems. We value scientific rigor, encourage publication, and support conference participation. If you want to do research that ships, this is the team. The Role We are seeking an exceptional Principal Applied Scientist to set the scientific direction for our life sciences AI portfolio. You will be the scientific leader who defines research agendas, architects novel approaches, and delivers models and methods that give our customers capabilities that did not previously exist. This is a rare role that combines deep expertise in LLM reasoning and agentic AI with applied impact in life sciences. You will innovate on how large language models reason, plan, and act in complex scientific domains, while applying domain knowledge in biology to ensure models produce scientifically valid outputs. The problems span multiple fronts: - How do you build LLM-based agentic systems that correctly reason over clinical protocols, regulatory standards, and complex multi-step scientific workflows? - How do you develop model customization and training methods that let customers get state-of-the-art results from foundation models? - How do you adapt and extend protein and antibody models so customers can fine-tune on proprietary sequence data and get therapeutically relevant outputs? You will work across drug discovery (protein engineering, antibody design) and clinical trial operations (agentic automation, structured reasoning, domain adaptation). You will own end-to-end scientific solutions from research through production, and your work will directly shape the tools that thousands of scientists use daily. Key job responsibilities - Set the scientific vision and research agenda for LLM reasoning, agentic AI, and biological model customization across the portfolio - Innovate on LLM reasoning, planning, and agentic approaches for complex scientific and regulatory workflows - Develop model customization methods (fine-tuning, RLHF, retrieval augmentation, domain adaptation) that enable customers to train better models on their own data with less effort - Advance methods to adapt and extend biological foundation models for customer-specific therapeutic applications - Solve open research problems in faithful reasoning, multi-step planning, and tool use in high-stakes scientific domains - Partner with Life Sciences domain experts and customers to understand their hardest scientific challenges and translate those into tractable research problems - Publish at top-tier venues and build the team's external scientific reputation - Mentor applied scientists across the team while maintaining significant personal research contribution - Collaborate with product and engineering to ensure research translates into shipped products that serve customers at scale - Influence multi-year research roadmaps through deep scientific expertise and customer understanding A day in the life - Push a new reasoning approach into production that measurably improves outputs for a pharma customer's workflow - Design and run experiments to validate a novel fine-tuning method, then ship it as a capability customers can use immediately - Unblock a delivery milestone by diagnosing why a model is failing on a new class of inputs and implementing a fix - Meet with a customer's scientific team to scope what the next model release needs to do for them - Review a teammate's experimental results, sharpen the approach, and help get it over the finish line - Publish results from shipped work at a top venue, closing the loop between research and impact - Prototype a new idea that could become the next major capability in the product
US, WA, Seattle
Interested in modeling and understanding customer behavior through machine learning, artificial intelligence, and data mining over TB scale data with huge business impact on millions of customers? Join our team of Scientists developing models to model customer behavior and optimize the customer experience with Amazon Prime. This includes understanding who our customers are, long-term value of the Prime membership program, and creating the right personalized framework for content and subscription optimization. As an AI/ML expert, you will partner directly with product owners to intake, build, and directly apply your modeling solutions. There are numerous scientific and technical challenges you will get to tackle in this role, such as optimizing/fine-tuning GenAI/LLM solutions for Prime personalization, building GenAI foundation models, global scalability of models, combinatorial optimization, cold start problem, accelerated experimentation, short/long term goals modeling, and multi-step optimization leading to reinforcement learning of the customer journey. We employ techniques from GenAI/LLMs, supervised/semi-supervised learning, deep learning, transformer architectures, using outcomes from causal Econometric modeling, and Reinforcement learning. As the central science team within Prime, our expertise gets routinely called upon to weigh in on a variety of topics. We also emphasize the need and value of scientific research and have developed a strong publication and patent record (internally/externally) which you will be a part of. You will also utilize and be exposed to the latest in ML technologies and infrastructure: AWS technologies (EMR/Spark, Sagemaker, DynamoDB, S3, ClaudeCode), various AI/ML algorithms and techniques (Deep Learning, GenAI/LLMs, transformers, supervised/unsupervised/semi-supervised/reinforcement learning), and statistical modeling techniques. - Stay abreast of current literature in the field and advance/build novel science solutions leveraging SoTA solutions. - Build and develop AI/ML models and supporting infrastructure at TB scale, in coordination with software engineering teams. - Leverage Deep Learning and GenAI solutions for building foundation models and personalized optimization solution. - Develop offline policy estimation tools and integrate with measurement systems/econometric models. - Establish scalable, efficient, automated processes for large scale data analyses, science development, science validation and model implementation. - Analyze and extract relevant information from large amounts of Amazon’s historical business data to help automate and optimize key processes. - Work closely with the business to understand their problem space, identify the opportunities and formulate the problems. - Use AI/machine learning, data mining, statistical techniques and others to create actionable, meaningful, and scalable solutions for the business problems. - Design, develop and evaluate highly innovative models and statistical approaches to understand and predict customer behavior and to solve business problems. Key job responsibilities Key job responsibilities - Stay abreast of current literature in the field and advance/build novel science solutions leveraging SoTA solutions. - Build and develop AI/ML models and supporting infrastructure at TB scale, in coordination with software engineering teams. - Leverage Deep Learning and GenAI solutions for building foundation models and personalized optimization solution. - Develop offline policy estimation tools and integrate with measurement systems/econometric models. - Establish scalable, efficient, automated processes for large scale data analyses, science development, science validation and model implementation. - Analyze and extract relevant information from large amounts of Amazon’s historical business data to help automate and optimize key processes. - Work closely with the business to understand their problem space, identify the opportunities and formulate the problems. - Use AI/machine learning, data mining, statistical techniques and others to create actionable, meaningful, and scalable solutions for the business problems. - Design, develop and evaluate highly innovative models and statistical approaches to understand and predict customer behavior and to solve business problems.