MLSys 2021: Bridging the divide between machine learning and systems

Amazon distinguished scientist and conference general chair Alex Smola on what makes MLSys unique — both thematically and culturally.

Smola skyline.cropped.small.png
Alex Smola, Amazon vice president and distinguished scientist

The Conference on Machine Learning and Systems (MLSys), which starts next week, is only four years old, but Amazon scientists already have a rich history of involvement with it. Amazon Scholar Michael I. Jordan is on the steering committee; vice president and distinguished scientist Inderjit Dhillon is on the board and was general chair last year; and vice president and distinguished scientist Alex Smola, who is also on the steering committee, is this year’s general chair.

As the deep-learning revolution spread, MLSys was founded to bridge two communities that had much to offer each other but that were often working independently: machine learning researchers and system developers.

Conference registration still open

Learn more about Amazon’s involvement with MLSys 2021, including paper presentations and workshop participation. Registration for the conference is still open, with the very low fees of $25 for students and $100 for academics and professionals.

“If you look at the big machine learning conferences, they mostly focus on, ‘Okay, here's a cool algorithm, and here are the amazing things that it can do. And by the way, it now recognizes cats even better than before,’” Smola says. “They're conferences where people mostly show an increase in capability. At the same time, there are systems conferences, and they mostly care about file systems, databases, high availability, fault tolerance, and all of that. 

“Now, why do you need something in-between? Well, because quite often in machine learning, approximate is good enough. You don't necessarily need such good guarantees from your systems. If you lower the requirement, you can do things cheaper, faster, or more scalably.”

Sys for ML, ML for sys

At the same time, as deep learning’s popularity grew, it was natural to ask whether it could help allocate resources in computer systems.

“This is, ultimately, what a lot of systems papers do,” Smola says. “They are along the lines of, Should I start a machine? Should I end one? How many devices should I schedule for a job? When do I decide that a machine has failed? How much redundancy do I need? So you can ask yourself, Well, given that these are a lot of resource decisions, can I use machine learning to predict what an optimal or at least a better strategy will be to handle those resource decisions?”

Should I start a machine? Should I end one? How many devices should I schedule for a job? ... Can I use machine learning to predict what an optimal or at least a better strategy will be?
Alex Smola

Papers accepted to MLSys, Smola explains, feature research in both directions — machine learning for systems and systems for machine learning. As an example, he pulls up the program listing for the conference session on Communication and Storage, on Tuesday, April 6.

“This is very much a systems session,” Smola says. “But even there, it covers both directions. For instance, the paper ‘In-network aggregation for shared machine learning clusters’ is about how you can do operations cheaply to facilitate more machine learning. But another paper is about how to use machine learning to make those storage systems themselves better.”

Cultural fusion

MLSys doesn’t just represent a merger of research programs, Smola says; it also represents a merger of cultures — which can make for some lively discussion.

“In the systems community, essentially, unless you actually have a working system, they won't take you seriously,” Smola says. “That makes the conference a little bit interesting, because you have two different cultures. You have the machine learning culture, where it's more like, ‘Hey, here is an impressionist painting of what could be. Next paper, please.’ And then the systems community, which is a lot more rigorous in terms of, ‘Well, here's something that actually works, and hey, we've demonstrated it. And by the way, maybe there's a product that's actually shipping now with it.’ And that makes the conference interesting, because those two cultures usually don't mix quite that much. And this maybe gives the systems papers a slightly more theoretical bent and the machine learning papers a slightly more empirical one.”

At this year’s MLSys, one of the additions that Smola oversaw is the introduction of a daylong Chips and Compilers Symposium, which brings the conversation about system design for machine learning down to the metal — the chip level. The symposium was organized by Mu Li, a senior principal scientist with Amazon Web Services.

“There are events like Hot Chips and Cool Chips where NVIDIA, Intel, AMD, ARM, and others show up and demonstrate the latest silicon,” Smola says. “But the silicon is only half the equation. So we figured this would be a good place to bring these two communities much more closely together. This is a community-building exercise.”

Like all computer science conferences in the past year, MLSys has moved online. The advantage of that, Smola says, is that it has drastically reduced the price of registration — $25 for students and $100 for academics and professionals.

“It's super affordable for anybody,” Smola says.

Related content

US, WA, Seattle
Economists in this role partner with business stakeholders to distill complex problems into testable economic questions and generate actionable insights. They collaborate with engineers and scientists to estimate models on large-scale data, design pilots, measure impact, and scale successful prototypes into improved policies and programs. They leverage AI tools to scale economic study for broader business impact. They communicate findings to business leaders, incorporate feedback, and deliver customer-centric solutions at scale.
US, NY, New York
Are you passionate about solving big problems from ground-up? Do you enjoy building new state-of-the-art products at internet scale? Come lead the innovation in this startup team, vertical ad products. This is a green field problem without a known answer or a pattern to follow. We have ambitious vision to simplify full funnel advertising solutions, at scale, with specialized agentic AI-powered models and diversify the demand to strategic verticals including finserv, autos, locals.. etc. We are seeking an experienced Applied Scientist to drive innovation in our Ads Foundational Model. In this individual contributor role, you will apply advanced machine learning techniques to improve advertiser performance and customer experience. Key job responsibilities As an Applied Scientist on this team, you will: 1. Develop and drive the science strategy for Ads Foundational Model (Ads-FM), aligning it with the program's objectives and overall business goals. 2. Identify high-impact opportunities within Ads-FM program and lead the ideation, planning, and execution of science initiatives to address them. 3. Build and deploy machine learning models using computer vision, natural language processing, and deep learning to evaluate and enhance ad effectiveness. 4. Develop algorithms that extract meaningful signals from image, video, and audio content to predict and improve customer engagement 5. Leverage Amazon's extensive data repository to create predictive models that generate actionable recommendations for more compelling ad creative 6. Collaborate with business leaders and cross-functional teams to implement ML-powered solutions 7. Contribute to the ML roadmap for the Ads-FM program through innovation and research.
US, WA, Seattle
This role will contribute to developing the Economics and Science products and services in the Fee domain, with specialization in supply chain systems and fees. Through the lens of economics, you will develop causal links for how Amazon, Sellers and Customers interact. You will be a key and senior scientist, advising Amazon leaders how to price our services. You will work on developing frameworks and scaleable, repeatable models supporting optimal pricing and policy in the two-sided marketplace that is central to Amazon's business. The pricing for Amazon services is complex. You will partner with science and technology teams across Amazon including Advertising, Supply Chain, Operations, Prime, Consumer Pricing, and Finance. We are looking for an experienced Principal Economist to improve our understanding of seller Economics, enhance our ability to estimate the causal impact of fees, and work with partner teams to design pricing policy changes. In this role, you will provide guidance to scientists to develop econometric models to influence our fee pricing worldwide. You will lead the development of causal models to help isolate the impact of fee and policy changes from other business actions, using experiments when possible, or observational data when not. Key job responsibilities The ideal candidate will have extensive Economics knowledge, demonstrated strength in practical and policy relevant structural econometrics, strong collaboration skills, proven ability to lead highly ambiguous and large projects, and a drive to deliver results. They will work closely with Economists, Data / Applied Scientists, Strategy Analysts, Data Engineers, and Product leads to integrate economic insights into policy and systems production. Familiarity with systems and services that constitute seller supply chains is a plus but not required. About the team The Stores Economics and Sciences team is a central science team that supports Amazon's Retail and Supply Chain leadership. We tackle some of Amazon's most challenging economics and machine learning problems, where our mandate is to impact the business on massive scale.
US, CA, San Diego
The Private Brands team is looking for a Research Scientist to join the team in building science solutions at scale. Our team applies Optimization, Machine Learning, Statistics, Causal Inference, and Econometrics/Economics to derive actionable insights about the complex economy of Amazon’s retail business and develop Statistical Models and Algorithms to drive strategic business decisions and improve operations. We are an interdisciplinary team of Scientists, Engineers, and Economists. Key job responsibilities You will work with business leaders, scientists, and economists to translate business and functional requirements into concrete deliverables, including the design, development, testing, and deployment of highly scalable optimization solutions and ML models. This is a unique, high visibility opportunity for someone who wants to have business impact, dive deep into large-scale problems, enable measurable actions on the consumer economy, and work closely with scientists and economists. As a Research Scientist, you bring business and industry context to science and technology decisions. You set the standard for scientific excellence and make decisions that affect the way we build and integrate algorithms. Your solutions are exemplary in terms of algorithm design, clarity, model structure, efficiency, and extensibility. You tackle intrinsically hard problems, acquiring expertise as needed. You decompose complex problems into straightforward solutions. We are particularly interested in candidates with experience in Operations Research and predictive models and working with distributed systems. Academic and/or practical background in Operations Research, Machine Learning and Reinforcement Learning are particularly relevant for this position. To know more about Amazon science, Please visit https://www.amazon.science
US, CA, Palo Alto
Alexa for Shopping (previously Rufus) is seeking a Senior Manager, Applied Science to lead multidisciplinary teams of Applied Scientists and Machine Learning Engineers building next-generation conversational AI and multi-agent systems powering customer-facing experiences at scale. This leader will drive both scientific innovation and execution across large language models (LLMs), agent orchestration, retrieval and grounding systems, evaluation frameworks, and scalable AI infrastructure. The role requires a combination of deep technical judgment, organizational leadership, product and engineering partnership, and operational excellence. The ideal candidate has a strong track record of building high-performing science and engineering teams, translating ambiguous business problems into scalable AI solutions, and delivering measurable customer impact through applied machine learning and generative AI technologies. Key job responsibilities - Lead and grow teams of Applied Scientists and Machine Learning Engineers working on conversational AI and multi-agent orchestration systems. - Define and drive technical strategy for large-scale generative AI systems, including LLM routing, prompting, grounding, memory, tool use, personalization, and response optimization. - Partner closely with Product, Engineering, and Tech leadership to align AI investments with long-term business and customer goals. - Drive end-to-end delivery of production AI systems balancing quality, latency, scalability, safety, and operational reliability. - Establish scientific and engineering best practices across experimentation, evaluation, model iteration, and production deployment. - Lead roadmap prioritization and execution across research innovation and product delivery timelines. - Build scalable evaluation methodologies and quality frameworks for multilingual and global customer experiences. - Mentor and develop technical leaders across both science and engineering disciplines. - Foster a high-performance culture centered on customer obsession, innovation, operational excellence, and strong cross-functional collaboration.
US, NY, New York
We are seeking a Human-Robot Interaction (HRI) Applied Scientist to develop cutting-edge interactions that make robots feel alive, personal, and fun. In this role, you will focus on verbal and non-verbal conversational systems, social dynamics, memory, and long-term relationship formation between robots, their environments, and the people they interact with. Your contributions will be essential in advancing robotics by enabling expressive, socially intelligent, and trustworthy interactions between robots and humans. Key job responsibilities - Develop interactive systems that leverage large language models, multimodal inputs and outputs, reinforcement learning from human feedback, or other advanced techniques to achieve fluid, engaging, and socially appropriate robot behavior - Design and implement intelligent conversational systems that handle turn-taking, grounding, interruption, and incorporates context drawn from a robot's physical environment and shared history with a user - Integrate perceptual sensor streams including gaze, facial expression, gesture, posture, and more to understand social context and produce coherent, lifelike interactions. - Develop memory and personalization systems that allow robots to form lasting relationships with individual users, learn their environments, and adapt their behavior over weeks and months - Stay updated on advancements in HRI, NLP, multimodal AI, and cognitive and social science to apply cutting-edge techniques to robot interaction challenges - Lead technical projects from conception through production deployment - Mentor junior scientists and engineers - Bridge research initiatives with practical engineering implementation
IN, KA, Bengaluru
Do you want to join an innovative team of scientists applying machine learning and advanced statistical techniques to protect Amazon customers and enable a trusted eCommerce experience? Are you excited about modeling terabytes of data and building state-of-the-art algorithms to solve complex, real-world fraud and risk challenges? Do you enjoy owning end-to-end machine learning problems, directly influencing customer experience and company profitability, while collaborating in a diverse, high-performing team? If so, the Amazon Buyer Risk Prevention (BRP) Machine Learning team may be the right fit for you. We are seeking an Applied Scientist to design, develop, and deploy advanced algorithmic systems that safeguard millions of transactions every day. In this role, you will independently drive model development from problem formulation to production deployment, build scalable ML solutions, and leverage emerging technologies—including Generative AI and LLMs—to enhance fraud detection and next-generation risk prevention systems. Key job responsibilities Own end-to-end development of machine learning models for large-scale risk management systems Analyze large volumes of historical and real-time data to identify fraud patterns and emerging risk trends Design, develop, validate, and deploy innovative models to production environments Apply GenAI/LLM technologies to automate risk evaluation and improve operational efficiency Collaborate closely with software engineering teams to implement scalable, real-time model solutions Partner with operations and business stakeholders to translate risk insights into measurable impact Establish scalable and automated processes for data analysis, model experimentation, validation, and monitoring Track model performance and business metrics; communicate insights clearly to technical and non-technical stakeholders Research and implement novel machine learning and statistical methodologies
IN, KA, Bengaluru
Do you want to join an innovative team applying machine learning and advanced statistical techniques to protect Amazon customers and enable a trusted eCommerce experience? Are you excited about working with large-scale datasets and developing models that solve real-world fraud and risk challenges? If so, the Amazon Buyer Risk Prevention (BRP) Machine Learning team may be the right fit for you. We are seeking an Applied Scientist to help develop scalable machine learning solutions that safeguard millions of transactions every day. In this role, you will partner with senior scientists and engineers to translate business problems into data-driven solutions, build and evaluate models, and contribute to next-generation risk prevention systems, including applications of Generative AI and LLM technologies. Key job responsibilities Apply machine learning and statistical techniques to build and improve risk management models Analyze large-scale historical data to identify risk patterns and emerging trends Develop, validate, and deploy innovative models under the guidance of senior scientists Experiment with emerging technologies, including GenAI/LLMs, to enhance automation and risk evaluation Collaborate closely with software engineers to implement models in real-time production systems Partner with operations and business teams to improve risk policies and operational efficiency Build scalable, automated pipelines for data analysis, model training, and validation Monitor model performance and provide clear reporting on key risk and business metrics Research and prototype new modeling approaches to improve system performance
IN, KA, Bengaluru
Do you want to join an innovative team of scientists applying machine learning and advanced statistical techniques to protect Amazon customers and enable a trusted eCommerce experience? Are you excited about modeling terabytes of data and building state-of-the-art algorithms to solve complex, real-world fraud and risk challenges? Do you enjoy owning end-to-end machine learning problems, directly influencing customer experience and company profitability, while collaborating in a diverse, high-performing team? If so, the Amazon Buyer Risk Prevention (BRP) Machine Learning team may be the right fit for you. We are seeking an Applied Scientist to design, develop, and deploy advanced algorithmic systems that safeguard millions of transactions every day. In this role, you will independently drive model development from problem formulation to production deployment, build scalable ML solutions, and leverage emerging technologies—including Generative AI and LLMs—to enhance fraud detection and next-generation risk prevention systems. Key job responsibilities Own end-to-end development of machine learning models for large-scale risk management systems Analyze large volumes of historical and real-time data to identify fraud patterns and emerging risk trends Design, develop, validate, and deploy innovative models to production environments Apply GenAI/LLM technologies to automate risk evaluation and improve operational efficiency Collaborate closely with software engineering teams to implement scalable, real-time model solutions Partner with operations and business stakeholders to translate risk insights into measurable impact Establish scalable and automated processes for data analysis, model experimentation, validation, and monitoring Track model performance and business metrics; communicate insights clearly to technical and non-technical stakeholders Research and implement novel machine learning and statistical methodologies
IN, KA, Bengaluru
Do you want to lead the development of advanced machine learning systems that protect millions of customers and power a trusted global eCommerce experience? Are you passionate about modeling terabytes of data, solving highly ambiguous fraud and risk challenges, and driving step-change improvements through scientific innovation? If so, the Amazon Buyer Risk Prevention (BRP) Machine Learning team may be the right place for you. We are seeking a Senior Applied Scientist to define and drive the scientific direction of large-scale risk management systems that safeguard millions of transactions every day. In this role, you will lead the design and deployment of advanced machine learning solutions, influence cross-team technical strategy, and leverage emerging technologies—including Generative AI and LLMs—to build next-generation risk prevention platforms. Key job responsibilities Lead the end-to-end scientific strategy for large-scale fraud and risk modeling initiatives Define problem statements, success metrics, and long-term modeling roadmaps in partnership with business and engineering leaders Design, develop, and deploy highly scalable machine learning systems in real-time production environments Drive innovation using advanced ML, deep learning, and GenAI/LLM technologies to automate and transform risk evaluation Influence system architecture and partner with engineering teams to ensure robust, scalable implementations Establish best practices for experimentation, model validation, monitoring, and lifecycle management Mentor and raise the technical bar for junior scientists through reviews, technical guidance, and thought leadership Communicate complex scientific insights clearly to senior leadership and cross-functional stakeholders Identify emerging scientific trends and translate them into impactful production solutions