Priya Ponnapalli, director of applied science at the Amazon ML Solutions Lab, smiles at the camera with her arms folded
As director of applied science at the Amazon ML Solutions Lab, Priya Ponnapalli leads a global team of scientists, engineers, and product managers who help AWS customers identify and implement their most important machine learning opportunities.
Christophe Testi

Helping AWS customers accelerate success via machine learning

Priya Ponnapalli leads the Amazon Machine Learning Solutions Lab, fostering inclusion and growth for her team along the way.

Two hockey players face off over the puck. Which one is likely to prevail? Fans can now get a real-time tip from a new National Hockey League stat, Face-Off Probability, powered by Amazon Web Services (AWS). The in-game hockey probability is just one of many ways machine learning is showing up in daily life, from sports to healthcare to finance.

The possibilities for AWS customers are vast, and many of those ideas are cutting-edge ones that have never been tried before. As director of applied science at the Amazon ML Solutions Lab, Priya Ponnapalli leads a global team of scientists, engineers, and product managers who help AWS customers identify and implement their most important machine learning opportunities.

The demand for her team's expertise is large and growing, according to Ponnapalli, who joined the lab as a principal scientist nearly four years ago. Other AWS sports partnerships include helping to create the National Football League’s real-time Next Gen Stats and new design specifications for F1 race cars.

Discovering machine learning innovations

Sports leagues make up one segment within a broad portfolio of ML Solutions Lab customers that includes automotive, manufacturing, healthcare and life sciences, and financial sector customers.

"We've got nearly 100 engagements with customers globally across all industries, and no two engagements are alike," Ponnapalli says. Her current focus: building a scalable organization needed to support increasing AWS customer demand.

"One of the most important things I do is invest in growing my talent and growing my leaders," she says. "I'm always encouraging my team to think big, look around corners for what’s possible, and anticipate how best we can serve our customers."

Last year, Business Insider named Ponnapalli to its list of 100 people transforming business, recognizing her work in leading businesses into the machine learning landscape.

"I got included along with many heroes that I admire and I just felt very honored," Ponnapalli says. "Of course, it's reflective of all the good work that my team does."

An ML Solutions Lab relationship often begins with a discovery workshop, Ponnapalli explains, where the customer shares what their biggest challenges and opportunities are, as well as what kind of data assets they have. That workshop then informs use cases for the AWS team to envision and build.

"Sometimes customers come to us with an open-ended charter. Others come to us with a very specific problem, like, 'We want to detect acoustic anomalies to monitor equipment performance and anticipate failures on our manufacturing floor,'” she says. "It varies, but our process is rooted in Amazon's working backwards philosophy."

From math to machine learning

Growing up in Hyderabad, India, Ponnapalli always loved math. Because she went to an all-girls school, she says, there was no stereotyping about what one gender could or could not do. Her parents instilled confidence in her as well.

"I've had a lot of strong role models throughout my life. They've all been very inspirational and always made me feel like I could do anything that I wanted to," she says. "I want to be able to create that same environment for others through my leadership of my team."

Related content
The senior economist knows what it means to pursue a career path like hers, and she’s determined to help others along the way.

After earning her bachelor's degree in electronics and communications engineering at Osmania University in Hyderabad, Ponnapalli went to the University of Texas at Austin, where she got her master's and doctorate degrees in electrical and computer engineering.

Coming out of undergrad, she was very interested in digital signal processing. A class in graduate school on signal processing for genomics turned out to be pivotal for her career; the professor of the class, Orly Alter, invited Ponnapalli to join her lab and became her PhD thesis advisor.

Alter's course was also Ponnapalli's introduction to machine learning. Building on that foundation and her thesis, she and Alter co-founded Eigengene, which uses artificial intelligence to analyze cancer genome data and create personalized diagnostics and prognostics. They developed algorithms designed to find patterns within diverse, high-dimensional datasets known as tensors.

As she conducted research related to tensor decompositions, Ponnapalli stumbled across a lot of finance forums where the same questions were being asked. "I realized that these algorithms are data-agnostic. They are industry-agnostic, with broad application within multiple areas," she says.

She dropped off her resume with Bloomberg at a UT Austin career fair late one week, interviewed over the weekend, and got a job offer that Monday. At Bloomberg, she developed a social media analytics tool called Bloomberg Social Velocity that alerted clients to spikes in social activity and market sentiment about companies. Lead data science roles at JP Morgan Chase and Genentech followed.

"I've always enjoyed working at the intersection of multiple disciplines," Ponnapalli says. "I truly believe that's where the magic happens, where there's a lot of cross-pollination of ideas."

The opportunity to work across different industry sectors while maintaining a focus on machine learning led Ponnapalli to apply for a position with the ML Solutions Lab. In addition to her role at Amazon, Ponnapalli teaches machine learning to business leaders as faculty at Rutgers University.

"I'm most excited about solving problems with real-world impact," she says. "Machine learning has the potential to help us solve some of the most complex and challenging problems of our time, like cancer and climate change."

Related content
New programs with Georgia Tech and the University of Southern California are established; existing Columbia University program expands.

She notes that with so many opportunities in machine learning, from scientists to product managers to engineers, anyone with an interest should not be afraid to pursue a job in the field. Given the availability of online resources, she adds, it's never been easier to learn. Plus, the field needs a diverse pool of talent.

"Creating inclusive workspaces is a cornerstone of my leadership style. I've used my position and whatever privilege and success that has come to me to help others and hire a diverse team," she says. "This is a field that impacts all of us — the products that we build need to work for everybody."

Research areas

Related content

US, WA, Seattle
Prime Video is a first-stop entertainment destination offering customers a vast collection of premium programming in one app available across thousands of devices. Prime members can customize their viewing experience and find their favorite movies, series, documentaries, and live sports – including Amazon MGM Studios-produced series and movies; licensed fan favorites; and programming from Prime Video add-on subscriptions such as Apple TV+, Max, Crunchyroll and MGM+. All customers, regardless of whether they have a Prime membership or not, can rent or buy titles via the Prime Video Store, and can enjoy even more content for free with ads. Are you interested in shaping the future of entertainment? Prime Video's technology teams are creating best-in-class digital video experience. As a Prime Video technologist, you’ll have end-to-end ownership of the product, user experience, design, and technology required to deliver state-of-the-art experiences for our customers. You’ll get to work on projects that are fast-paced, challenging, and varied. You’ll also be able to experiment with new possibilities, take risks, and collaborate with remarkable people. We’ll look for you to bring your diverse perspectives, ideas, and skill-sets to make Prime Video even better for our customers. With global opportunities for talented technologists, you can decide where a career Prime Video Tech takes you! As an Applied Scientist in the Prime Video Playback Intelligence Organization, you will have deep subject matter expertise in applied machine learning and data science, with specializations in video streaming optimization, information retrieval, anomaly detection and root-causing systems, large language models and generative AI across various modalities. Key job responsibilities - Work with multiple teams of scientists, engineers, and product managers to translate business and functional requirements into concrete deliverables leading strategic efforts to enhance customer quality of experiences. - Work on problems spaces such as: improving the customer playback quality of experience across Video on Demand, Live Events and Linear Content. - Reduce the time/cost/effort to optimize the customer experience as well as detect, root-cause, and mitigate defects in the customer experience. You’ll seek to understand the depth and nuance of streaming video at scale and identify opportunities to grow our business and improve customer quality of experience via principled ML/AI solutions. - Lead integration of new algorithms and processes into existing modeling stacks, simplify and streamline the existing modeling stacks, and develop testing and evaluation strategies. Ultimately, you'll work backwards from the desired outcomes and lead the way on determining the ideal solution (statistical techniques, traditional ML, GenAI, etc). A day in the life We love solving challenging and hard problems in our quest to innovate on behalf of our customers and provide the best video streaming experience. We push the boundaries to leverage and invent technologies which help create unrivaled experiences for our customers to help us move fast in a growing and changing environment. We use data to guide our decisions, work closely with our engineering and product counterparts, and partner with other Science teams as well as academic institutions to learn and guide in an environment of innovation.
IN, KA, Bengaluru
Selection Monitoring team is responsible for making the biggest catalog on the planet even bigger. In order to drive expansion of the Amazon catalog, we develop advanced ML/AI technologies to process billions of products and algorithmically find products not already sold on Amazon. We work with structured, semi-structured and Visually Rich Documents using deep learning, NLP and image processing. The role demands a high-performing and flexible candidate who can take responsibility for success of the system and drive solutions from research, prototype, design, coding and deployment. We are looking for Applied Scientists to tackle challenging problems in the areas of Information Extraction, Efficient crawling at internet scale, developing ML models for website comprehension and agents to take multi-step decisions. You should have depth and breadth of knowledge in text mining, information extraction from Visually Rich Documents, semi structured data (HTML) and advanced machine learning. You should also have programming and design skills to manipulate Semi-Structured and unstructured data and systems that work at internet scale. You will encounter many challenges, including: - Scale (build models to handle billions of pages), - Accuracy (requirements for precision and recall) - Speed (generate predictions for millions of new or changed pages with low latency) - Diversity (models need to work across different languages, market places and data sources) You will help us to - Build a scalable system which can algorithmically extract information from world wide web. - Intelligently cluster web pages, segment and classify regions, extract relevant information and structure the data available on semi-structured web. - Build systems that will use existing Knowledge Base to perform open information extraction at scale from visually rich documents. Key job responsibilities - Use AI, NLP and advances in LLMs/SLMs and agentic systems to create scalable solutions for business problems. - Efficiently Crawl web, Automate extraction of relevant information from large amounts of Visually Rich Documents and optimize key processes. - Design, develop, evaluate and deploy, innovative and highly scalable ML models, esp. leveraging latest advances in RL-based fine tuning methods like DPO, GRPO etc. - Work closely with software engineering teams to drive real-time model implementations. - Establish scalable, efficient, automated processes for large scale model development, model validation and model maintenance. - Lead projects and mentor other scientists, engineers in the use of ML techniques. - Publish innovation in research forums.
US, WA, Seattle
This role will contribute to developing the Economics and Science products and services in the Fee domain, with specialization in supply chain systems and fees. Through the lens of economics, you will develop causal links for how Amazon, Sellers and Customers interact. You will be a key and senior scientist, advising Amazon leaders how to price our services. You will work on developing frameworks and scalable, repeatable models supporting optimal pricing and policy in the two-sided marketplace that is central to Amazon's business. The pricing for Amazon services is complex. You will partner with science and technology teams across Amazon including Advertising, Supply Chain, Operations, Prime, Consumer Pricing, and Finance. We are looking for an experienced Economist to improve our understanding of seller Economics, enhance our ability to estimate the causal impact of fees, and work with partner teams to design pricing policy changes. In this role, you will provide guidance to scientists to develop econometric models to influence our fee pricing worldwide. You will lead the development of causal models to help isolate the impact of fee and policy changes from other business actions, using experiments when possible, or observational data when not. Key job responsibilities The ideal candidate will have extensive Economics knowledge, demonstrated strength in practical and policy relevant structural econometrics, strong collaboration skills, proven ability to lead highly ambiguous and large projects, and a drive to deliver results. They will work closely with Economists, Data / Applied Scientists, Strategy Analysts, Data Engineers, and Product leads to integrate economic insights into policy and systems production. Familiarity with systems and services that constitute seller supply chains is a plus but not required. About the team The Stores Economics and Sciences team is a central science team that supports Amazon's Retail and Supply Chain leadership. We tackle some of Amazon's most challenging economics and machine learning problems, where our mandate is to impact the business on massive scale.
US, NY, New York
We are looking for detail-oriented, organized, and responsible individuals who are eager to learn how to apply their structural econometrics skillsets to solve real world problems. The intern will work in the area of Amazon Private Brands and develop models to improve our product selection. Our PhD Economist Internship Program offers hands-on experience in applied economics, supported by mentorship, structured feedback, and professional development. Interns work on real business and research problems, building skills that prepare them for full-time economist roles at Amazon and beyond. You will learn how to build data sets and perform applied econometric analysis collaborating with economists, scientists, and product managers. These skills will translate well into writing applied chapters in your dissertation and provide you with work experience that may help you with placement. These are full-time positions at 40 hours per week, with compensation being awarded on an hourly basis. About the team The Amazon Private Brands science advance team applies Machine Learning, Statistics and Econometrics/economics to solve high-impact business problems, develop prototypes for Amazon-scale science solutions, and optimize key business functions of Amazon Private Brands and other Amazon orgs. We are an interdisciplinary team, using science and technology and leveraging the strengths of engineers and scientists to build solutions for some of the toughest business problems at Amazon, covering areas such as pricing, discovery, negotiation, forecasting, supply chain and product selection/development.
US, WA, Seattle
Innovators wanted! Are you an entrepreneur? A builder? A dreamer? This role is part of an Amazon Special Projects team that takes the company’s Think Big leadership principle to the extreme. We focus on creating entirely new products and services with a goal of positively impacting the lives of our customers. No industries or subject areas are out of bounds. If you’re interested in innovating at scale to address big challenges in the world, this is the team for you. Here at Amazon, we embrace our differences. We are committed to furthering our culture of inclusion. We have thirteen employee-led affinity groups, reaching 40,000 employees in over 190 chapters globally. We are constantly learning through programs that are local, regional, and global. Amazon’s culture of inclusion is reinforced within our 16 Leadership Principles, which remind team members to seek diverse perspectives, learn and be curious, and earn trust. Our team highly values work-life balance, mentorship and career growth. We believe striking the right balance between your personal and professional life is critical to life-long happiness and fulfillment. We care about your career growth and strive to assign projects and offer training that will challenge you to become your best.
US, CA, San Francisco
Amazon has launched a new research lab in San Francisco to develop foundational capabilities for useful AI agents. We’re enabling practical AI to make our customers more productive, empowered, and fulfilled. Our work leverages large vision language models (VLMs) with reinforcement learning (RL) and world modeling to solve perception, reasoning, and planning to build useful enterprise agents. Our lab is a small, talent-dense team with the resources and scale of Amazon. Each team in the lab has the autonomy to move fast and the long-term commitment to pursue high-risk, high-payoff research. We’re entering an exciting new era where agents can redefine what AI makes possible. Key job responsibilities You will contribute directly to AI agent development in an applied research role to improve the multi-model perception and visual-reasoning abilities of our agent. Daily responsibilities including model training, dataset design, and pre- and post-training optimization. You will be hired as a Member of Technical Staff.
US, CA, Pasadena
The Amazon Center for Quantum Computing (CQC) is a multi-disciplinary team of scientists, engineers, and technicians, on a mission to develop a fault-tolerant quantum computer. We are looking to hire an Instrument Control Engineer to join our growing software team. You will work closely with our experimental physics and control hardware development teams to enable their work characterizing, calibrating, and operating novel quantum devices. The ideal candidate should be able to translate high-level science requirements into software implementations (e.g. Python APIs/frameworks, compiler passes, embedded SW, instrument drivers) that are performant, scalable, and intuitive. This requires someone who (1) has a strong desire to work within a team of scientists and engineers, and (2) demonstrates ownership in initiating and driving projects to completion. This role has a particular emphasis on working directly with our control hardware designers and vendors to develop instrument software for test and measurement. Inclusive Team Culture Here at Amazon, it’s in our nature to learn and be curious. Our employee-led affinity groups foster a culture of inclusion that empower us to be proud of our differences. Ongoing events and learning experiences, including our Conversations on Race and Ethnicity (CORE) and AmazeCon conferences, inspire us to never stop embracing our uniqueness. Diverse Experiences Amazon values diverse experiences. Even if you do not meet all of the qualifications and skills listed in the job description, we encourage candidates to apply. If your career is just starting, hasn’t followed a traditional path, or includes alternative experiences, don’t let it stop you from applying. Mentorship & Career Growth We’re continuously raising our performance bar as we strive to become Earth’s Best Employer. That’s why you’ll find endless knowledge-sharing, mentorship and other career-advancing resources here to help you develop into a better-rounded professional. Work/Life Balance We value work-life harmony. Achieving success at work should never come at the expense of sacrifices at home, which is why we strive for flexibility as part of our working culture. When we feel supported in the workplace and at home, there’s nothing we can’t achieve in the cloud. Export Control Requirement Due to applicable export control laws and regulations, candidates must be either a U.S. citizen or national, U.S. permanent resident (i.e., current Green Card holder), or lawfully admitted into the U.S. as a refugee or granted asylum, or be able to obtain a US export license. If you are unsure if you meet these requirements, please apply and Amazon will review your application for eligibility. Key job responsibilities - Work with control hardware developers, as a “subject matter expert” on the software interfaces around our control hardware - Collaborate with external control hardware vendors to understand and refine integration strategies - Implement instrument drivers and control logic in Python and/or a low-level languages, including C++ or Rust - Contribute to our compiler backend to enable the efficient execution of OpenQASM-based experiments on our next-generation control hardware - Benchmark system performance and help define key performance metrics - Ensure new features are successfully integrated into our Python-based experimental software stack - Partner with scientists to actively contribute to the codebase through mentorship and documentation We are looking for candidates with strong engineering principles, a bias for action, superior problem-solving, and excellent communication skills. Working effectively within a team environment is essential. As an Instrument Control Engineer embedded in a broader science organization, you will have the opportunity to work on new ideas and stay abreast of the field of experimental quantum computation. A day in the life Your time will be spent on projects that extend functional capabilities or performance of our internal research software stack. This requires working backwards from the needs of science staff in the context of our larger experimental roadmap. You will translate science and software requirements into design proposals balancing implementation complexity against time-to-delivery. Once a design proposal has been reviewed and accepted, you’ll drive implementation and coordinate with internal stakeholders to ensure a smooth roll out. Because many high-level experimental goals have cross-cutting requirements, you’ll often work closely with other engineers or scientists or on the team. About the team You will be joining the Software group within the Amazon Center of Quantum Computing. Our team is comprised of scientists and software engineers who are building scalable software that enables quantum computing technologies.
US, WA, Seattle
The AWS Marketplace & Partner Services Science team seeks an Applied Scientist to drive innovation across multiple AI domains, including Context Engineering in Agent-based Systems, Agent Evaluations, and Next-generation Recommendations. This role will be instrumental in revolutionizing how customers discover solutions for cloud migrations and modernization initiatives. The ideal candidate thrives in an environment of practical application and scientific rigor, demonstrating both technical excellence and business acumen. They should be passionate about collaboration and contributing to a culture of continuous learning and innovation. This role directly influences how thousands of AWS customers discover and implement software solutions, making it crucial for AWS Marketplace's growth and customer success. The position offers the opportunity to shape the future of AI-driven customer solution recommendations while working with innovative technologies at AWS scale. Key job responsibilities - Design and optimize context engineering solutions for large language models and agent-based systems - Establish innovative and useful evaluation strategies for measuring agent performance and effectiveness - Collaborate with cross-functional teams, such as Product and Engineering leaders, to translate scientific innovations into customer value - Publishing research or contributing to internal/external publications About the team The AWS Marketplace & Partner Services Science team is at the forefront of developing and deploying AI/ML systems that serve multiple critical stakeholders: - AWS Customers: Through the AWS Marketplace, we support Discovery tools that streamline cloud adoption and innovation. - AWS Partners: Via Partner Central, we offer advanced tools and insights to enhance collaboration and drive mutual growth. - Internal AWS Sellers: We equip our sales force with data-driven recommendations to better serve our customers and partners. Our primary objective is to accelerate cloud migrations and modernizations, fostering innovation for AWS customers while simultaneously supporting the growth and success of our extensive partner network. Why AWS Amazon Web Services (AWS) is the world’s most comprehensive and broadly adopted cloud platform. We pioneered cloud computing and never stopped innovating — that’s why customers from the most successful startups to Global 500 companies trust our robust suite of products and services to power their businesses. Inclusive Team Culture Here at AWS, it’s in our nature to learn and be curious. Our employee-led affinity groups foster a culture of inclusion that empower us to be proud of our differences. Ongoing events and learning experiences, including our Conversations on Race and Ethnicity (CORE) and AmazeCon conferences, inspire us to never stop embracing our uniqueness. Work/Life Balance We value work-life harmony. Achieving success at work should never come at the expense of sacrifices at home, which is why we strive for flexibility as part of our working culture. When we feel supported in the workplace and at home, there’s nothing we can’t achieve in the cloud. Mentorship and Career Growth We’re continuously raising our performance bar as we strive to become Earth’s Best Employer. That’s why you’ll find endless knowledge-sharing, mentorship and other career-advancing resources here to help you develop into a better-rounded professional. Diverse Experiences Amazon values diverse experiences. Even if you do not meet all of the preferred qualifications and skills listed in the job description, we encourage candidates to apply. If your career is just starting, hasn’t followed a traditional path, or includes alternative experiences, don’t let it stop you from applying.
US, TX, Austin
Amazon Security is looking for a talented and driven Applied Scientist II to spearhead Generative AI acceleration within the Secure Third Party Tools (S3T) organization. The S3T team has bold ambitions to re-imagine security products that serve Amazon's pace of innovation at our global scale. This role will focus on leveraging large language models and agentic AI to transform third-party security risk management, automate complex vendor assessments, streamline controllership processes, and dramatically reduce assessment cycle times. You will drive builder efficiency and deliver bar-raising security engagements across Amazon. Key job responsibilities Lead the research, design, and development of GenAI-powered solutions to enhance the security and governance of third-party tools across Amazon Develop and fine-tune large language models (LLMs) and other ML models tailored to security use cases, including risk detection, anomaly identification, and automated compliance Collaborate with cross-functional teams — including Security Engineers, Software Development Engineers, and Product Managers — to translate scientific innovations into scalable, production-ready systems Define and drive the GenAI roadmap for the S3T organization, influencing strategy and prioritization Conduct rigorous experimentation, evaluate model performance, and iterate rapidly to deliver measurable impact Stay current with the latest advancements in GenAI and applied ML research, and bring relevant innovations into Amazon's security ecosystem Mentor junior scientists and contribute to a culture of scientific excellence within the team About the team Security is central to maintaining customer trust and delivering delightful customer experiences. At Amazon, our Security organization is designed to drive bar-raising security engagements. Our vision is that Builders raise the Amazon security bar when they use our recommended tools and processes, with no overhead to their business. Diverse Experiences Amazon Security values diverse experiences. Even if you do not meet all of the qualifications and skills listed in the job description, we encourage candidates to apply. If your career is just starting, hasn’t followed a traditional path, or includes alternative experiences, don’t let it stop you from applying. Why Amazon Security? At Amazon, security is central to maintaining customer trust and delivering delightful customer experiences. Our organization is responsible for creating and maintaining a high bar for security across all of Amazon’s products and services. We offer talented security professionals the chance to accelerate their careers with opportunities to build experience in a wide variety of areas including cloud, devices, retail, entertainment, healthcare, operations, and physical stores. Inclusive Team Culture In Amazon Security, it’s in our nature to learn and be curious. Ongoing DEI events and learning experiences inspire us to continue learning and to embrace our uniqueness. Addressing the toughest security challenges requires that we seek out and celebrate a diversity of ideas, perspectives, and voices. Training & Career Growth We’re continuously raising our performance bar as we strive to become Earth’s Best Employer. That’s why you’ll find endless knowledge-sharing, training, and other career-advancing resources here to help you develop into a better-rounded professional. Work/Life Balance We value work-life harmony. Achieving success at work should never come at the expense of sacrifices at home, which is why flexible work hours and arrangements are part of our culture. When we feel supported in the workplace and at home, there’s nothing we can’t achieve.
US, WA, Seattle
Innovators wanted! Are you an entrepreneur? A builder? A dreamer? This role is part of an Amazon Special Projects team that takes the company’s Think Big leadership principle to the next-level. We focus on creating entirely new products and services with a goal of positively impacting the lives of our customers. No industries or subject areas are out of bounds. If you’re interested in innovating at scale to address big challenges in the world, this is the team for you. Here at Amazon, we embrace our differences. We are committed to furthering our culture of inclusion. We have thirteen employee-led affinity groups, reaching 40,000 employees in over 190 chapters globally. We are constantly learning through programs that are local, regional, and global. Amazon’s culture of inclusion is reinforced within our 16 Leadership Principles, which remind team members to seek diverse perspectives, learn and be curious, and earn trust. Key job responsibilities * Develop, deploy, and operate scalable bioinformatics analysis workflows on AWS * Evaluate and incorporate novel bioinformatic approaches to solve critical business problems * Originate and lead the development of new data collection workflows with cross-functional partners * Partner with laboratory science teams on design and analysis of experiments About the team Our team highly values work-life balance, mentorship and career growth. We believe striking the right balance between your personal and professional life is critical to life-long happiness and fulfillment. We care about your career growth and strive to assign projects and offer training that will challenge you to become your best.