How controllers from industrial machinery can coordinate multitask machine learning

Instead of compromising among parameter updates dictated by different training objectives, ControlG allocates computational capacity to objectives sequentially and dynamically.

Key takeaways
  • ControlG uses industrial control system principles — specifically proportional-integral-derivative (PID) controllers — to coordinate multiple conflicting training objectives in graph machine learning by allocating computational capacity sequentially rather than blending gradients at each step.
  • The framework operates across three time scales: estimating per-objective difficulty through spectral-demand and interference metrics, optimizing per-epoch computation allocation using log-hypervolume sensitivity, and tracking the allocation plan via PID feedback loops.
  • ControlG eliminates three common multitask learning failures — disagreement (negative transfer), drift (changing objective relevance), and drought (objectives starved to zero weight) — by temporally separating objectives instead of forcing per-step compromise.
Was this answer helpful?

Training a machine learning model to handle multiple objectives simultaneously is a bit like trying to follow GPS directions to several destinations at once: the routes often conflict, and compromising between them can leave you farther from every destination.

A paper we presented at this year’s International Conference on Machine Learning (ICML) addresses this problem in the context of graph self-supervised learning (graph SSL), where the goal is to train a neural network to process graph data. Graph SSL objectives include inferring links between graph nodes, reconstructing nodes that have been masked out, and maximizing the mutual information between a given node and the nodes in its neighborhood.

Our framework, ControlG, borrows an idea from industrial control systems: rather than blending all objectives together at every training step, it dedicates computational capacity to one objective at a time and lets a proportional-integral-derivative (PID) controller decide which objective needs attention next. Karish Grover, an Amazon PhD fellow, performed this work during an internship at Amazon Web Services, and Amazon Scholar Christos Faloutsos and I served as his mentors.

controlg.jpg
The key insight behind ControlG. Per-step mixing (left) forces compromise when objectives conflict. ControlG separates objectives in time (center), dedicating a separate computational block to each. The learned schedule (right) is interpretable: early training explores all objectives (link prediction, mutual information, reconstruction, and contrastive learning); mid-training prioritizes mutual information after determining that another objective has been interfering with it; and late training focuses on the reconstruction objective, which has been lagging.

The problem: Multitask tug-of-war

The goal of graph self-supervised learning is to learn useful representations of graph data that can be used in downstream tasks like node classification. Research in the area has produced a rich tool kit of training objectives, each encoding different structural intuitions about the data. Link prediction captures local connectivity. Feature reconstruction captures node attributes. Contrastive methods capture invariant features. No single objective dominates across all datasets and downstream tasks, so a natural strategy is to combine several objectives.

For each batch of training examples, the machine learning algorithm calculates a gradient: a vector that indicates the direction and distance we should move in the parameter space. Based on the gradient, the algorithm updates the model’s parameters.

The standard way to handle multiple objectives is per-step mixing: at every training step, blend gradients from all objectives into a single update. This makes every parameter update a compromise. When objectives disagree about the direction in which to modify parameters, three types of failure occur:

  1. Disagreement: Conflicting gradients cause negative transfer, where optimizing one objective actively degrades another.
  2. Drift: An objective that helps early in training may become redundant later, but fixed or slowly adapting weights cannot track this shift.
  3. Drought: Adaptive weighting schemes can starve objectives by driving their weights toward zero, making it impossible to tell whether an objective ever meaningfully shaped the learned representation.

Coordination is a scheduling problem

Our key insight is that multitask coordination is fundamentally a temporal allocation problem. Rather than asking, "How should I blend these objectives right now?", we should ask, "Which objective should receive the next allocation of my computational budget?"

This reframing has a surprising consequence: even random scheduling, where you pick an objective uniformly at random for each block of training steps, often matches or beats sophisticated gradient-manipulation methods. On node clustering, random scheduling (average rank 5.0) outperforms AutoSSL (7.3), WAS (10.0), ParetoGNN (8.1), PCGrad (7.8), and CAGrad (8.4). The temporal separation alone eliminates instantaneous gradient conflict.

But random scheduling leaves performance on the table. Some objectives need more computational capacity than others at different points in training. ControlG uses the PID controller to allocate adaptively. PID controllers are feedback loop controllers often used in industrial settings to manage processes that require continuous adjustment and automated control. You can find such systems in both industrial machinery and consumer devices, from your car’s cruise control system to a high-end espresso machine regulating water temperature.

ControlG: Sense, plan, control

ControlG decomposes multitask coordination into three loops, each operating at a different time scale. The loops draw on the theory of Pareto efficiency: in multiobjective optimization, the Pareto front is a boundary in parameter space along which it is impossible to improve the outcome on one objective without diminishing it on another.

1. Sense (slow time scale): Estimate per-objective difficulty using two signals computed on the full training graph:

  • Spectral demand: When a graph neural network (GNN) aggregates information from neighboring nodes, it naturally smooths signals across the graph, much the way averaging nearby pixels blurs an image. Some objectives produce learning signals that vary smoothly (neighboring nodes want similar updates), while others produce sharply varying signals (neighboring nodes want contradictory updates). We measure this by computing how much each objective's desired update direction disagrees between connected nodes (formally, the Rayleigh quotient of the per-node gradients with respect to the graph structure). The sharper the disagreement, the harder it is for the GNN's smoothing architecture to make progress. We prove this formally: this disagreement score (Rayleigh quotient) upper-bounds how much progress a single training step can achieve.
  • Interference: How much does optimizing this objective conflict with the optimization of other objectives? We use the multiple-gradient descent algorithm, which calculates a gradient that reduces error on at least one objective without increasing it on any others, as a measurement oracle: its weights identify which objectives are currently constraining the Pareto trade-off.
Overview of ControlG.jpg.001.png
Overview of ControlG. The framework decomposes multitask graph self-supervised learning into three coupled loops operating at different time scales. (1) Sense estimates per-objective difficulty via spectral-demand and interference signals. (2) Plan converts these into a Pareto-aware allocation target. (3) Control tracks the plan with a PID controller that selects single-task blocks.

2. Plan (epoch timescale): Convert difficulty estimates into a target allocation of computational capacity across objectives. For this, we use the log-hypervolume metric, which measures the distance between the current parameter values (the reference point) and the Pareto front. In particular, we consider log-hypervolume sensitivities, which measure how strongly improvement on one objective would increase the log-hypervolume. In the context of graph SSL, this naturally prioritizes objectives that are lagging (close to the reference point) while tempering allocation by estimated difficulty. The planner produces a target fraction of compute blocks per objective for each epoch.

3. Control (block time scale): Track the allocation plan with a proportional-integral-derivative (PID) controller. The proportional term prioritizes objectives behind schedule. The integral term eliminates steady-state tracking bias. The derivative term damps oscillations.

Results

We evaluate ControlG on nine graph benchmarks spanning homophilic graphs (graphs where connected nodes are likely to share features, such as Cora, CiteSeer, PubMed, Coauthor-CS, Wiki-CS), heterophilic networks (graphs where connected nodes tend to have dissimilar features, such as Chameleon, Squirrel, Actor), and large-scale graphs (ogbn-arxiv, 169K nodes). Across three downstream tasks (node classification, link prediction, and node clustering), ControlG achieves average ranks of 1.4, 1.9, and 1.8 respectively, consistently outperforming all baselines.

Key findings

  • Homophilic graphs: ControlG delivers strong gains over the next-best multitask method (Cora +1.5% over CAGrad, PubMed +1.1% over PCGrad, Coauthor-CS +1.8% over CAGrad on node classification).
  • Heterophilic graphs: Where gradient conflicts are most pronounced, ControlG outperforms all multitask baselines and remains competitive with the best single-objective method (masked-feature reconstruction), which benefits from avoiding conflict entirely but lacks breadth.
  • Scale: On ogbn-arxiv (169K nodes), ControlG achieves 72.86% node classification accuracy, a 1.2 percentage point improvement over the next-best multitask method (CAGrad at 71.62%).
  • Efficiency: ControlG adds modest overhead (16-31 milliseconds per step depending on dataset) compared to simple scheduling (8-15 milliseconds) but remains substantially faster than heavyweight methods like AutoSSL (125-414 milliseconds) and ParetoGNN (35-764 milliseconds).
    Wall-clock time per optimizer step on Cora.jpg
    Wall-clock time per optimizer step on Cora, a dataset of scientific papers in which graph edges indicate citation. ControlG (teal) incurs modest overhead compared to simple scheduling baselines but is significantly faster than heavyweight methods like AutoSSL and ParetoGNN.

Interpretable and auditable training

Beyond performance, ControlG provides visibility into the training process. The scheduling timeline shows exactly when each objective received allocations of computational capacity. The deficit traces, which indicate the difference between the planned allocation and the actual allocation, confirm that the PID controller tracks allocation, and the state trajectories show how difficulty estimates adapt to training dynamics.

Task-scheduling timeline produced by ControlG.jpg
Task-scheduling timeline produced by ControlG. Top: Which objective was selected at each training block. Bottom: Running proportion of blocks allocated to each task. ControlG dynamically shifts focus, exploring broadly early, concentrating on high-interference tasks mid-training, and bursting on lagging tasks late.

This auditability matters in practice: when a downstream task unexpectedly degrades, the training log reveals which objectives drove the learned representation and when.

Every component matters

Removing components in isolation confirms what each piece of ControlG contributes:

  • Removing the planner (uniform allocation) causes the largest drop (up to 3.4% on some datasets), confirming that adaptive allocation is essential.
  • Removing both state signals (spectral demand and interference) yields similar degradation, showing that the planner's effectiveness depends on accurate difficulty estimates.
  • Removing spectral demand diminishes performance across all graph types, while removing interference matters most for heterophilic graphs, where cross-task conflicts are stronger.
  • Replacing the PID controller with independent and identically distributed sampling from the plan degrades performance by 1-2%, demonstrating that deficit tracking improves allocation fidelity.

Broader implications

While we demonstrate ControlG on graph self-supervised learning, the framework addresses a general problem: how to coordinate multiple training objectives without forcing per-step compromise. The control-theoretic decomposition (sense difficulty, plan allocation, track with feedback) is applicable whenever

  • multiple objectives share parameters and can conflict;
  • the relative importance of objectives changes over training; or
  • interpretability of the training process matters.

We are exploring applications to LLM continual learning and multitask fine tuning, where similar tug-of-war dynamics arise when models are trained on diverse instruction-following, reasoning, and safety objectives simultaneously.

Acknowledgments

This work was led by Karish Grover (Amazon AI PhD fellowship '25-'27, Carnegie Mellon University) during his internship at Amazon, with Han Xie (applied scientist, AWS AI), Sixing Lu (applied scientist, AWS AI), Xiang Song (applied scientist, AWS AI), Christos Faloutsos (Amazon Scholar, Carnegie Mellon University), and me. The code is available as open source.

Research areas

Related content

US, WA, Seattle
About Sponsored Products and Brands The Sponsored Products and Brands (SPB) team at Amazon Ads is re-imagining the advertising landscape through generative AI technologies, revolutionizing how millions of customers discover products and engage with brands across Amazon.com and beyond. We are at the forefront of re-inventing advertising experiences, bridging human creativity with artificial intelligence to transform every aspect of the advertising lifecycle from ad creation and optimization to performance analysis and customer insights. We are a passionate group of innovators dedicated to developing responsible and intelligent AI technologies that balance the needs of advertisers, enhance the shopping experience, and strengthen the marketplace. If you're energized by solving complex challenges and pushing the boundaries of what's possible with AI, join us in shaping the future of advertising. About our team The General Shopping Intelligence (GSI) team is a highly motivated, collaborative, and fun-loving group with a strong entrepreneurial spirit and bias for action. We provide advanced real-time machine learning services that connect shoppers with the right ads across all platforms and surfaces worldwide. Through deep understanding of both shoppers and products, we help shoppers discover new products they love, enable advertisers to reach their customers most efficiently, and help Amazon continuously innovate on behalf of all customers. We are seeking a motivated Applied Scientist who loves to innovate at the intersection of customer experience, deep learning, generative AI and high-scale machine learning systems. If you're energized by solving complex challenges and pushing the boundaries of what's possible with AI, join us in shaping the future of advertising. Key job responsibilities As an Applied Scientist, you will: * Leverage Generative AI and Large Language Models (LLMs) to mine complex behavioral data, deriving deep, actionable shopper insights that identify customer experience gaps and unlock new business opportunities. * Design and develop scalable machine learning and GenAI models focused on shopper intent and preference modeling, ensuring a rapid path from prototype to production. * Partner closely with engineering teams to architect and deploy end-to-end GenAI solutions into production, integrating advanced insights directly into real-time, customer-facing systems. * Drive the scalability, efficiency, and automation of large-scale model training and real-time inference systems, pioneering the LLM infrastructure required to support next-generation GenAI workloads at Amazon Ads scale. * Design and run rigorous A/B experiments to quantify the business and customer impact of GenAI-driven shopper insights, performing advanced statistical analysis to guide iterative production rollouts. * Conduct applied research in novel generative AI techniques (e.g., fine-tuning, RAG, agentic workflows) to optimize the shopper experience and drive performance across all aspects of the Sponsored Products and Brands business.
US, WA, Seattle
We are seeking a Principal Applied Scientist to own the scientific vision across Agentic WorkSpaces. This is a foundational role spanning the full portfolio — Personal, Applications, and Core, and the agentic surfaces (WS4Builders and WorkSpaces for Agents). You will define how we measure, improve, and guarantee the performance of AI agents and human-AI teams. A core part of the role is defining the science agenda itself — identifying which problems are most worth solving and where the highest-leverage bets lie. Directions worth exploring might include Organizational Intelligence (turning institutional knowledge into agent-consumable skills), AI Agent Experience / AiAX (agent observability and autonomous remediation), and contextual, behavioral security that adapts enforcement in real time for human and agent sessions — but these are illustrative examples, not a fixed roadmap, and many other directions are possible. You will help define which ones we pursue. The problems you will solve do not have established industry patterns. You will set the direction for the science of how AI agents and people perceive, reason about, and act reliably within computing environments at enterprise scale. Key job responsibilities - Set the long-term scientific vision: Define what best-in-class agent performance, evaluation, and learning look like across Agentic WorkSpaces — for computer-using agents and human-AI teams alike. Identify the unsolved scientific problems, chart a multi-year research roadmap, and secure buy-in from VP-level leadership. - Solve highly ambiguous, novel problems: Independently frame and deliver solutions to foundational challenges in agent perception, reasoning, evaluation, reliability, and human-AI collaboration — problems where neither the approach nor the success criteria are pre-defined. - Own the evaluation and measurement foundation: Build the benchmarks, datasets, and metrics that quantify agent and team accuracy, cost, productivity, and safety across the portfolio and diverse enterprise workflows, and that gate what we ship. - Drive cross-organizational scientific alignment: Work across partner teams (AgentCore, Bedrock model teams, Identity, Security, the MCP ecosystem) and across the Applied AI Solutions product portfolio to shape how models and agent frameworks are applied, and ensure scientific decisions compose into a coherent system. - Deliver measurable business impact: Ensure research translates to customer outcomes: higher task accuracy, lower cost-per-action, faster time-to-production, measurable productivity for human-AI teams, and the trust that lets enterprises scale agent workflows. - Raise the scientific bar: Establish rigor in experimentation, evaluation, and reproducibility. Mentor and grow senior scientists and engineers. Set the standard for applied science quality across the organization. - Advance the state of the art: Contribute to the external technical community through publications, patents, and open-source contributions that position AWS as the leader in the science of secure agent-computer interaction and human-AI teamwork. About the team AWS Applied AI Solutions' (AAIS) vision is every business innovating with Amazon AI teammates. Our mission is to build delightful AI solutions that improve human capabilities and business outcomes. The Agentic WorkSpaces organization within AAIS envisions a world where people, teams, and AI collaborate securely from anywhere to create unprecedented value for every organization. We build lovable products that empower every business to unlock the full potential of human-AI teamwork, driving smarter decisions, greater creativity, more value, and faster innovation with confidence. Amazon Agentic WorkSpaces (AAWS) is building the world's most lovable, secure, and trusted always-on workspace where AI agents and humans work as partners behind enterprise-grade security. Our portfolio spans persistent desktops (Personal), application streaming (Applications), and Core, and is evolving into the governed operating environment for the hybrid workforce: humans get AI-native desktops for their role, and agents get governed desktops scoped to their task, with administrators managing both as one. This surface includes WS4Builders (an AI-native environment for builders) and WorkSpaces for Agents (W4A) — enabling AI agents to work the way humans do, with access to real applications, real interfaces, and real computing environments. Enterprises want to use AI agents for critical business workloads that touch legacy desktop applications and mainframes, yet 75% of organizations run legacy applications that lack modern APIs, and 90% of corporate data remains locked in systems never designed for agents. Agentic WorkSpaces solves this: it gives enterprises a secure, governed environment where agents and humans operate both legacy and modern applications directly, just as an employee would, without costly migrations.
IN, KA, Bengaluru
Amazon Health Services (One Medical) About Us: At Health AI, we're revolutionizing healthcare delivery through innovative AI-enabled solutions. As part of Amazon Health Services and One Medical, we're on a mission to make quality healthcare more accessible while improving patient outcomes. Our work directly impacts millions of lives by empowering patients and enabling healthcare providers to deliver more meaningful care. Role Overview: We're seeking an Applied Scientist to join our dynamic team in building state of the art AI/ML solutions for healthcare. This role offers a unique opportunity to work at the intersection of artificial intelligence and healthcare, developing solutions that will shape the future of medical services delivery. Key job responsibilities • Lead end-to-end development of AI/ML solutions for Amazon Health organization, including Amazon Pharmacy and One Medical • Research, design, and implement state-of-the-art machine learning models, with a focus on Large Language Models (LLMs) and Visual Language Models (VLMs) • Optimize and fine-tune models for production deployment, including model distillation for improved latency • Drive scientific innovation while maintaining a strong focus on practical business outcomes • Collaborate with cross-functional teams to translate complex technical solutions into tangible customer benefits • Contribute to the broader Amazon Health scientific community and help shape our technical roadmap
US, WA, Seattle
Interested in modeling and understanding customer behavior through machine learning, artificial intelligence, and data mining over TB scale data with huge business impact on millions of customers? Join our team of Scientists developing models to model customer behavior and optimize the customer experience with Amazon Prime. This includes understanding who our customers are, long-term value of the Prime membership program, and creating the right personalized framework for content and subscription optimization. As an AI/ML expert, you will partner directly with product owners to intake, build, and directly apply your modeling solutions. There are numerous scientific and technical challenges you will get to tackle in this role, such as optimizing/fine-tuning GenAI/LLM solutions for Prime personalization, building GenAI foundation models, global scalability of models, combinatorial optimization, cold start problem, accelerated experimentation, short/long term goals modeling, and multi-step optimization leading to reinforcement learning of the customer journey. We employ techniques from GenAI/LLMs, supervised/semi-supervised learning, deep learning, transformer architectures, using outcomes from causal Econometric modeling, and Reinforcement learning. As the central science team within Prime, our expertise gets routinely called upon to weigh in on a variety of topics. We also emphasize the need and value of scientific research and have developed a strong publication and patent record (internally/externally) which you will be a part of. You will also utilize and be exposed to the latest in ML technologies and infrastructure: AWS technologies (EMR/Spark, Sagemaker, DynamoDB, S3, ClaudeCode), various AI/ML algorithms and techniques (Deep Learning, GenAI/LLMs, transformers, supervised/unsupervised/semi-supervised/reinforcement learning), and statistical modeling techniques. - Stay abreast of current literature in the field and advance/build novel science solutions leveraging SoTA solutions. - Build and develop AI/ML models and supporting infrastructure at TB scale, in coordination with software engineering teams. - Leverage Deep Learning and GenAI solutions for building foundation models and personalized optimization solution. - Develop offline policy estimation tools and integrate with measurement systems/econometric models. - Establish scalable, efficient, automated processes for large scale data analyses, science development, science validation and model implementation. - Analyze and extract relevant information from large amounts of Amazon’s historical business data to help automate and optimize key processes. - Work closely with the business to understand their problem space, identify the opportunities and formulate the problems. - Use AI/machine learning, data mining, statistical techniques and others to create actionable, meaningful, and scalable solutions for the business problems. - Design, develop and evaluate highly innovative models and statistical approaches to understand and predict customer behavior and to solve business problems. Key job responsibilities Key job responsibilities - Stay abreast of current literature in the field and advance/build novel science solutions leveraging SoTA solutions. - Build and develop AI/ML models and supporting infrastructure at TB scale, in coordination with software engineering teams. - Leverage Deep Learning and GenAI solutions for building foundation models and personalized optimization solution. - Develop offline policy estimation tools and integrate with measurement systems/econometric models. - Establish scalable, efficient, automated processes for large scale data analyses, science development, science validation and model implementation. - Analyze and extract relevant information from large amounts of Amazon’s historical business data to help automate and optimize key processes. - Work closely with the business to understand their problem space, identify the opportunities and formulate the problems. - Use AI/machine learning, data mining, statistical techniques and others to create actionable, meaningful, and scalable solutions for the business problems. - Design, develop and evaluate highly innovative models and statistical approaches to understand and predict customer behavior and to solve business problems.
GB, London
In Amazon Advertising, we apply machine learning at massive scale to optimize the prediction, ranking, and bidding behind every ad — deciding, in milliseconds, which ads to show shoppers and how to value them. We're looking for an Applied Scientist to help make sure the ads shoppers see are the right ones for them. You'll work across the science of how we rank, value, and bid on ads for Amazon DSP (Amazon's Demand-Side Platform) — including how we judge whether an ad is a good fit for the page a shopper is on and for the shopper themselves. It's high-scale, low-latency, customer-facing science: your models run live in front of millions of shoppers under tight real-time constraints. The questions are genuinely open — how do you tell whether an ad is relevant to someone, how do you balance what's good for shoppers, advertisers, and Amazon, and how do you keep getting that right as shopping behavior and inventory shift underneath you? Your work will have real impact, and you'll have room to shape where we take it. A few things make this stand out: your models touch a huge share of the ads shoppers see every day, so even small improvements add up fast; you'll run modern ML live under strict latency limits, across regions and very different types of ad inventory; and the problem space is rich — from how we value and bid on ads, to keeping models stable as traffic shifts, to what makes an ad a good fit for a shopper. Key job responsibilities - Design and improve the models that decide how ads are ranked, valued, and priced — including how relevant an ad is to the page and the shopper. - Apply and extend state-of-the-art techniques across e.g. ranking, deep learning, and information retrieval. - Own problems end to end: frame them, prototype, experiment, and ship them to production. - Balance competing objectives — shopper experience, advertiser and publisher value, and Amazon's business — into models that hold up across placements and marketplaces. - Communicate your work clearly to both business and science audiences, tailoring how you share it to each. - Write and ship your own production code backed by strong engineering support — we're all builders here. - Move fast with the best tools available, including modern AI coding assistants and agents. A day in the life You might start by digging into last week's experiment results, then use an AI coding agent to get your next prototype built and ready to test in production. In the afternoon you could be sketching a new way to measure ad relevance, reading a recent paper that bears on it, and talking it through with a senior scientist on the team. You'll move between hands-on science, writing and shipping real production code, and making the calls on your own work. About the team We're a group of scientists and engineers based in Edinburgh and London, working to make Amazon's ads more performant and relevant. We sit within a larger team spread primarily across New York City and the UK, and we have a broad mandate to build and experiment. You'll work alongside senior applied scientists you can learn from, with the data and infrastructure to do the work well and room to grow — with opportunities to attend top conferences (e.g., NeurIPS, KDD, ICML) and take on more scope over time.
US, WA, Seattle
As part of the AWS Applied AI Solutions organization, we have a vision to provide end user applications, leveraging Amazon's unique experience and expertise, that are used by millions of companies worldwide to manage day-to-day operations. We will accomplish this by accelerating our customers' businesses through delivery of intuitive and differentiated technology solutions that solve enduring business challenges. We blend vision with curiosity and Amazon's real-world experience to build opinionated, turnkey solutions. Where customers prefer to buy over build, we become their trusted partner with solutions that are easy to adopt and easy to use. The Team Join the next science revolution at AWS Life Sciences Applied AI Solutions, where you'll work alongside world-class scientists to build AI that transforms how therapeutics are discovered, developed, and brought to patients. We're out to revolutionize how medicines are discovered, developed, and brought to patients, powered by a new generation of AI. Our team tackles some of the hardest open problems at the intersection of frontier AI and life sciences. We apply biological foundation models, large language models, and agentic reasoning systems to life sciences problems, then put them into the hands of pharma, biotech, and diagnostics customers as applications and managed services they can fine-tune, tailor, and deploy on their own data. The science challenges are deep: how do you design agentic systems that reason correctly over complex biological, regulatory, and clinical logic? How do you enable customers to tailor foundation models to their proprietary data and get better outputs with less effort? How do you adapt models to reason faithfully in high-stakes scientific and regulatory domains? Today we're focused on two areas. In drug design, our products (including Amazon Bio Discovery) accelerate discovery by giving bench scientists AI-guided protein engineering and antibody design capabilities. In clinical trials, we're building AI that automates and optimizes regulatory and clinical development workflows. We combine frontier research with production-scale delivery to put breakthrough science into the hands of customers solving humanity's hardest problems. We value scientific rigor, encourage publication, and support conference participation. If you want to do research that ships, this is the team. The Role We are seeking an exceptional Principal Applied Scientist to set the scientific direction for our life sciences AI portfolio. You will be the scientific leader who defines research agendas, architects novel approaches, and delivers models and methods that give our customers capabilities that did not previously exist. This is a rare role that combines deep expertise in LLM reasoning and agentic AI with applied impact in life sciences. You will innovate on how large language models reason, plan, and act in complex scientific domains, while applying domain knowledge in biology to ensure models produce scientifically valid outputs. The problems span multiple fronts: - How do you build LLM-based agentic systems that correctly reason over clinical protocols, regulatory standards, and complex multi-step scientific workflows? - How do you develop model customization and training methods that let customers get state-of-the-art results from foundation models? - How do you adapt and extend protein and antibody models so customers can fine-tune on proprietary sequence data and get therapeutically relevant outputs? You will work across drug discovery (protein engineering, antibody design) and clinical trial operations (agentic automation, structured reasoning, domain adaptation). You will own end-to-end scientific solutions from research through production, and your work will directly shape the tools that thousands of scientists use daily. Key job responsibilities - Set the scientific vision and research agenda for LLM reasoning, agentic AI, and biological model customization across the portfolio - Innovate on LLM reasoning, planning, and agentic approaches for complex scientific and regulatory workflows - Develop model customization methods (fine-tuning, RLHF, retrieval augmentation, domain adaptation) that enable customers to train better models on their own data with less effort - Advance methods to adapt and extend biological foundation models for customer-specific therapeutic applications - Solve open research problems in faithful reasoning, multi-step planning, and tool use in high-stakes scientific domains - Partner with Life Sciences domain experts and customers to understand their hardest scientific challenges and translate those into tractable research problems - Publish at top-tier venues and build the team's external scientific reputation - Mentor applied scientists across the team while maintaining significant personal research contribution - Collaborate with product and engineering to ensure research translates into shipped products that serve customers at scale - Influence multi-year research roadmaps through deep scientific expertise and customer understanding A day in the life - Push a new reasoning approach into production that measurably improves outputs for a pharma customer's workflow - Design and run experiments to validate a novel fine-tuning method, then ship it as a capability customers can use immediately - Unblock a delivery milestone by diagnosing why a model is failing on a new class of inputs and implementing a fix - Meet with a customer's scientific team to scope what the next model release needs to do for them - Review a teammate's experimental results, sharpen the approach, and help get it over the finish line - Publish results from shipped work at a top venue, closing the loop between research and impact - Prototype a new idea that could become the next major capability in the product
US, WA, Seattle
We are seeking a Senior Manager, Applied Science to build and lead the science organization across Agentic WorkSpaces. This is a foundational leadership role spanning the full portfolio — Personal, Applications, and Core, and the agentic surfaces (WS4Builders and WorkSpaces for Agents). You will hire, grow, and lead a team of applied scientists who define how we measure and improve the performance of AI agents and human-AI teams. A core part of the role is defining the science agenda itself — identifying which problems are most worth solving and where the highest-leverage bets lie. Directions worth exploring might include Organizational Intelligence (turning institutional knowledge into agent-consumable skills), AI Agent Experience / AiAX (agent observability and autonomous remediation), and contextual, behavioral security that adapts enforcement in real time for human and agent sessions — but these are illustrative examples, not a fixed roadmap, and many other directions are possible. You and your team will define which ones we pursue. The problems your team will solve do not have established industry patterns. You will set the scientific direction and build the team that determines how AI agents and people perceive, reason about, and act reliably within computing environments at enterprise scale. What You Will Do Build and lead the applied science team. Hire, develop, and retain a high-caliber team of applied scientists spanning the Agentic WorkSpaces portfolio. Set the bar for scientific talent, create the growth paths, and build the culture that makes AAWS a destination for the best agent and human-AI researchers. Own the science strategy across the portfolio. Direct the research agenda for how we measure and improve agents and human-AI teams: the benchmarks, task suites, and metrics (accuracy, cost-per-task, task completion, productivity) that turn subjective "it works" judgments into rigorous, reproducible measurement that gates what we ship. Define and drive high-leverage research directions. Work with your team to identify the problems most worth solving and shape the science agenda. Directions worth exploring might include how agents combine deterministic tool use (MCP) with visual reasoning from computer use; Organizational Intelligence and workflow learning (learning from expert recordings, voice annotations, and SOPs); and AI Agent Experience / AiAX (detecting when agents are stuck or degrading productivity and autonomously remediating) — these are illustrative starting points, and your team will weigh them against many other possibilities. Translate science into shipped product. Partner with engineering, product, and program leaders to move models, evaluation, and learning systems from prototype into a decade-old production service operating at massive scale, without compromising the reliability that customers depend on. Represent science in leadership and to customers. Be the scientific voice in org-level planning and roadmap decisions across AAWS, and engage directly with enterprise customers on how agent performance, safety, and human-AI productivity are measured and earned. Key job responsibilities Build and lead the applied science team. Hire, develop, and retain a high-caliber team of applied scientists spanning the Agentic WorkSpaces portfolio. Set the bar for scientific talent, create the growth paths, and build the culture that makes AAWS a destination for the best agent and human-AI researchers. Own the science strategy across the portfolio. Direct the research agenda for how we measure and improve agents and human-AI teams: the benchmarks, task suites, and metrics (accuracy, cost-per-task, task completion, productivity) that turn subjective "it works" judgments into rigorous, reproducible measurement that gates what we ship. Define and drive high-leverage research directions. Work with your team to identify the problems most worth solving and shape the science agenda. Directions worth exploring might include how agents combine deterministic tool use (MCP) with visual reasoning from computer use; Organizational Intelligence and workflow learning (learning from expert recordings, voice annotations, and SOPs); and AI Agent Experience / AiAX (detecting when agents are stuck or degrading productivity and autonomously remediating) — these are illustrative starting points, and your team will weigh them against many other possibilities. Translate science into shipped product. Partner with engineering, product, and program leaders to move models, evaluation, and learning systems from prototype into a decade-old production service operating at massive scale, without compromising the reliability that customers depend on. Represent science in leadership and to customers. Be the scientific voice in org-level planning and roadmap decisions across AAWS, and engage directly with enterprise customers on how agent performance, safety, and human-AI productivity are measured and earned. Set the long-term scientific vision and team strategy: Define what best-in-class agent performance, evaluation, and learning look like across Agentic WorkSpaces — for computer-using agents and human-AI teams alike. Chart a multi-year research roadmap, and build the team and plan to deliver it. Secure buy-in from VP-level leadership. Hire and grow scientific talent: Own recruiting, calibration, development, and retention for the science team. Mentor scientists toward senior and principal scope, and raise the scientific bar across the organization. Direct research on highly ambiguous, novel problems: Guide the team through foundational challenges in agent perception, reasoning, evaluation, reliability, and human-AI collaboration — problems where neither the approach nor the success criteria are pre-defined. Drive cross-organizational alignment: Work across partner teams (AgentCore, Bedrock model teams, Identity, Security, the MCP ecosystem) and across the Applied AI Solutions product portfolio, with product and engineering leadership, to ensure scientific decisions compose into a coherent product. Deliver measurable business impact: Ensure your team's research translates to customer outcomes: higher task accuracy, lower cost-per-action, faster time-to-production, measurable productivity for human-AI teams, and the trust that lets enterprises scale agent workflows. Establish scientific rigor and operational excellence: Set the standard for experimentation, evaluation, and reproducibility, and the mechanisms that keep the science organization productive and accountable. Advance the state of the art: Enable and champion contributions to the external technical community through publications, patents, and open-source work that position AWS as the leader in the science of secure agent-computer interaction and human-AI teamwork. About the team AWS Applied AI Solutions' (AAIS) vision is every business innovating with Amazon AI teammates. Our mission is to build delightful AI solutions that improve human capabilities and business outcomes. The Agentic WorkSpaces organization within AAIS envisions a world where people, teams, and AI collaborate securely from anywhere to create unprecedented value for every organization. We build lovable products that empower every business to unlock the full potential of human-AI teamwork, driving smarter decisions, greater creativity, more value, and faster innovation with confidence. Amazon Agentic WorkSpaces (AAWS) is building the world's most lovable, secure, and trusted always-on workspace where AI agents and humans work as partners behind enterprise-grade security. Our portfolio spans persistent desktops (Personal), application streaming (Applications), and Core, and is evolving into the governed operating environment for the hybrid workforce: humans get AI-native desktops for their role, and agents get governed desktops scoped to their task, with administrators managing both as one. This surface includes WS4Builders (an AI-native environment for builders) and WorkSpaces for Agents (W4A) — enabling AI agents to work the way humans do, with access to real applications, real interfaces, and real computing environments. Enterprises want to use AI agents for critical business workloads that touch legacy desktop applications and mainframes, yet 75% of organizations run legacy applications that lack modern APIs, and 90% of corporate data remains locked in systems never designed for agents. Agentic WorkSpaces solves this: it gives enterprises a secure, governed environment where agents and humans operate both legacy and modern applications directly, just as an employee would, without costly migrations.
IN, HR, Gurugram
Work on ML teams building large-scale forecasting and optimization systems that power Amazon’s global transportation network and directly impact customer experience and cost. As an Applied Scientist II, you will set scientific direction, mentor applied scientists, and partner with engineering and product leaders to deliver production-grade ML solutions at massive scale. Key job responsibilities 1. Lead and grow a high-performing team of Applied Scientists, providing technical guidance, mentorship, and career development. 2. Define and own the scientific vision and roadmap for ML solutions powering large-scale transportation planning and execution. 3. Guide model and system design across a range of techniques, including tree-based models, deep learning (LSTMs, transformers), LLMs, and reinforcement learning. 4. Ensure models are production-ready, scalable, and robust through close partnership with stakeholders. Partner with Product, Operations, and Engineering leaders to enable proactive decision-making and corrective actions. 5. Own end-to-end business metrics, directly influencing customer experience, cost optimization, and network reliability. 6. Help contribute to the broader ML community through publications, conference submissions, and internal knowledge sharing. A day in the life Your day includes reviewing model performance and business metrics, guiding technical design and experimentation, mentoring scientists, and driving roadmap execution. You’ll balance near-term delivery with long-term innovation while ensuring solutions are robust, interpretable, and scalable. Ultimately, your work helps improve delivery reliability, reduce costs, and enhance the customer experience at massive scale.
US, NY, New York
At Amazon Selection and Catalog Systems (ASCS), our mission is to power the online buying experience for customers worldwide so they can find, discover, and buy any product they want. We innovate on behalf of our customers to infer relationships between products in Amazon Catalog to drive the selection gateway for the search and browse experiences on the website. We're solving a fundamental AI challenge: establishing product identity and relationships at unprecedented scale. Using Generative AI, Visual Language Models (VLMs), and multimodal reasoning, we determine what makes each product unique and how products relate to one another across Amazon's catalog. The scale is staggering: billions of products, petabytes of multimodal data, millions of sellers, dozens of languages, and infinite product diversity—from electronics to groceries to digital content. The research challenges are immense. GenAI and VLMs hold transformative promise for catalog understanding, but we operate where traditional methods fail: ambiguous problem spaces, incomplete and noisy data, inherent uncertainty, reasoning across both images and textual data, and explaining decisions at scale. Establishing product identities and groupings requires sophisticated models that reason across text, images, and structured data—while maintaining accuracy and trust for high-stakes business decisions affecting millions of customers daily. Amazon's Item and Relationship Platform group is looking for an innovative and customer-focused applied scientist to help us make the world's best product catalog even better. In this role, you will partner with technology and business leaders to build new state-of-the-art algorithms, models, and services to infer product-to-product relationships that matter to our customers. You will pioneer advanced GenAI solutions that power next-generation agentic shopping experiences, working in a collaborative environment where you can experiment with massive data from the world's largest product catalog, tackle problems at the frontier of AI research, rapidly implement and deploy your algorithmic ideas at scale, across millions of customers. Key job responsibilities * Formulate novel research problems at the intersection of GenAI, multimodal learning, and large-scale information retrieval—translating ambiguous business challenges into tractable scientific frameworks * Design and implement leading models leveraging VLMs, foundation models, and agentic architectures to solve product identity, relationship inference, and catalog understanding at billion-product scale * Pioneer explainable AI methodologies that balance model performance with scalability requirements for production systems impacting millions of daily customer decisions * Own end-to-end ML pipelines from research ideation to production deployment—processing petabytes of multimodal data with rigorous evaluation frameworks * Define research roadmaps aligned with business priorities, balancing foundational research with incremental product improvements * Mentor peer scientists and engineers on advanced ML techniques, experimental design, and scientific rigor—building organizational capability in GenAI and multimodal AI * Represent the team in the broader science community—publishing findings, delivering tech talks, and staying at the forefront of GenAI, VLM, and agentic system research
IN, KA, Bengaluru
Amazon Ads is a multi-billion dollar global business that delivers advertising experiences across Amazon's owned-and-operated properties (including Prime Video, Twitch, Fire TV, and Amazon.com), third-party publisher networks, and emerging channels like generative AI-powered shopping experiences. As one of the fastest-growing segments of Amazon, we operate at unprecedented scale across desktop, mobile, connected TV, and emerging surfaces. Within Amazon Ads, Traffic Quality is a critical pillar of advertiser trust and marketplace integrity. Our mission is to build advanced capabilities that work at petabyte scale to detect sophisticated invalid traffic (IVT) which includes sophisticated non-human traffic, bot networks, and fraudulent engagement patterns across programmatic advertising. We are on a journey to establish Amazon Ads as an industry leader in traffic quality standards and transparency. Our research agenda focuses on staying ahead of adversarial actors through continuous innovation in detection methodologies, leveraging state-of-the-art techniques in deep learning and generative modeling, user behavior and multi-modal representation learning, anomaly detection, time-series analysis, and sparse labeling methods. We process billions of ad events daily, developing novel algorithms that balance precision and recall while operating under strict latency constraints. Our work directly protects hundreds of millions of dollars in advertiser spend annually while maintaining a seamless user experience. Key job responsibilities As a Data Scientist II in Traffic Quality, you will solve inherently hard problems in advertising fraud detection by applying advanced statistical techniques and machine learning. You'll work on systems that process billions of ad impressions and clicks per day, using Amazon's cloud services including EC2, S3, EMR, Sagemaker, and RedShift. - Define and frame new research problems in fraud detection where neither problem nor solution is well-defined. - Apply new machine learning approaches, models, and algorithms to detect sophisticated invalid traffic. - Apply domain knowledge to perform broad data analysis as a precursor to modeling and build business insights. - Work with unstructured and massive datasets to deliver results. - Produce research reports meeting top-tier external publication standards. - Mentor and develop junior scientists on the team. About the team Here are a few papers published by the team: 1/ [Scaling Generative Pre-training for User Ad Activity Sequences. AdKDD 2023.](https://assets.amazon.science/b7/42/03be071743d5a57cb1656e6caa34/scaling-generative-pre-training-for-user-ad-activity-sequences.pdf) 2/ [SLIDR: Real-time Robot Detection On Online Ads, IAAI 2023, Deployed Highly Innovative Applications of AI Track (AAAI 2023)](https://assets.amazon.science/75/2f/3b7106b143f38f7f4d2806388ace/real-time-detection-of-robotic-traffic-in-online-advertising.pdf) 3/ [Self-supervised Representation Learning Across Sequential and Tabular Features Using Transformers, NeurIPS 2022, First Table Representation Learning Workshop](https://openreview.net/forum?id=wIIJlmr1Dsk)