Michelle K. Lee
Michelle K. Lee, vice president of the Amazon Machine Learning Solutions Lab at Amazon Web Services
Credit: Moshe Zusman Photography Studio

How Michelle K. Lee plans to help businesses tap into the potential of machine learning

The head of Amazon's ML Solutions lab shares the lessons she learned leading a 200-year-old government agency — and why she's excited about the future.

Across many industries, machine learning is emerging as a critical technology for solving complex, real-world problems. From using data to predict health outcomes to making online transactions more secure, companies are finding new ways to use ML — and sometimes they need help.

Michelle K. Lee, in her role as vice president of the Amazon Machine Learning (ML) Solutions Lab at Amazon Web Services (AWS), wants to advance that process.

Prior to joining Amazon in 2019, Lee was an MIT CSAIL (formerly MIT Artificial Intelligence Lab) computer scientist, a tech executive who helped build a company that, like Amazon, grew quickly into a multi-national corporation, a professor, and a public servant. In the latter role, she served as the Under Secretary of Commerce for Intellectual Property and director of the United States Patent and Trademark Office (USPTO) from 2014 to 2017. In this position, Lee was the chief executive officer of one of the largest intellectual property offices in the world with around 13,000 employees and an annual budget in excess of $3 billion, and served as the principal advisor to the president on intellectual property policies.  She is the first woman to hold this position in American history.

Amazon Science recently talked with Lee about her experiences at the patent office, her interest in artificial intelligence, the untapped potential of machine learning, why she was drawn to the ML Solutions Lab, and more.

Q. How did you get interested in machine learning?

I was born and raised in Silicon Valley, so I’ve been around technology my entire life. As a young girl, I loved tinkering, building and making things. I fondly recall building, with my dad, the Heathkit hand-held radio and the TV that eventually sat in our living room. This led me to study engineering and computer science at MIT.  I first became interested in AI when I was a student at MIT. Back then, in the late ‘80s, everyone was excited about AI and how it might transform the world. That didn’t quite happen, but now that the cost of storage is lower, our computing power much greater, and cloud services more widely available, I do believe the time is ripe for AI and machine learning to achieve its promise and become widely available — to be democratized, if you will.

Q. How do you see that democratization being realized? 

More customers from a broader range of industries are starting to use machine learning, and I expect that adoption will continue to accelerate.  In the past, if I was in an area unrelated to the computing and machine learning industry, it was hard for me to tap into and take advantage of that functionality. Now I can be in a completely unrelated business, and I'm still able to explore, build, and deploy machine learning models to help improve my organization, to enhance my customer’s experience, or to solve a very challenging problem.

For example, NASA partnered with my team to use machine learning to understand, and ultimately predict, the occurrence of superstorms. Additionally, and more recently, data scientists from my team worked with AstraZeneca to help pathologists accelerate the classification of tissue samples by utilizing computer vision models. That reduced the time it takes to classify samples by 50%, which means their pharmaceutical research can move faster — that’s very exciting! For another customer, Cerner, one of the largest publicly traded healthcare IT companies, we were able to build a solution that allows researchers to query autotomized and anonymized patient data records. They were able to predict congestive heart failure up to 15 months before a clinical manifestation. These are just a few examples, but there are many more across a wide range of industries.

Q. What challenges remain?

We're in the early stages. If you think of it as a baseball game, the machine learning and AI journey is in the first of nine innings. It’s still hard for some organizations to find the best machine learning use case for their business. Identifying one’s highest-value use cases requires understanding the current state of machine learning technology, assessing your data and prioritizing the business needs of your organization. Once your best use cases have been identified, implementation is often a challenge, as many organizations lack the expertise on their teams, or even compliant access to their data, to implement the machine learning solutions.

Q. Where does the ML Solutions Lab fit in?

The Machine Learning Solutions Lab addresses each of these challenges. It pairs the customer's team with AWS machine learning experts who are data scientists. This team of data scientists and business consultants works to help identify and build machine learning solutions to address high-value machine learning opportunities and a path to production. Once we develop that plan, we can even provide a professional services team to help implement if needed.

We also offer educational training for technical team members, the same machine learning curriculum we use to train AWS engineers and scientists. For business leaders, there’s training aimed at teaching them ways to think about AI so they can better understand both what is possible and how AI might be used to address their business challenges.

Not every problem is solvable by machine learning, but business leaders today should have some understanding of AI and ML, and when it can be used to achieve operational efficiencies and competitive advantage.

Q. Has COVID-19 changed what you are doing?

We're seeing an increased use of AI and ML in a number of areas in response to the pandemic, from research to healthcare. Rarely before has the pace of research and publication been so furious. That’s understandable given the global medical crisis we face. While more research is good, it is hard for scientists to discover research relevant to their work given the exponentially increasing volume of information.

That’s why AWS built the CORD-19 Search tool using services like Amazon Comprehend Medical and Amazon Kendra. This new search tool, powered by machine learning and hosted at CORD19.aws, allows researchers to get answers to questions like, “What do we know about COVID-19 risk factors?” and “Are IL-6 inhibitors key to COVID-19?” or “Which medications were most beneficial in the 2002 SARS outbreak?”

Built on the Allen Institute for AI’s CORD-19 open research dataset of more than 128,000 research papers and other materials, this machine learning solution can extract relevant medical information from unstructured text and delivers robust natural-language query capabilities, helping to accelerate the pace of discovery. 

In the field of medical imaging, meanwhile, researchers are using machine learning to help recognize patterns in images, enhancing the ability of radiologists to indicate the probability of disease and to diagnose it earlier. More generally, all organizations are adjusting to the post-pandemic world, finding new ways to operate effectively and meet customer and employee needs as social distancing and quarantine measures remain in place. Machine learning is facilitating that shift by providing the tools to support remote communication, enable telemedicine, and protect food security, for example.

Q. What inspired you to choose Amazon?

In my prior position, I led a 200-year-old governmental agency, the United States Patent Trademark Office. Part of my job involved digitally transforming the agency. Because of my background at the MIT Artificial Intelligence Lab and with a big data company, I recognized that there was a tremendous opportunity to revolutionize the Patent Office’s business using AI and data analytics.

Michelle K. Lee's USPTO swearing in ceremony

We implemented some basic AI and data analytics solutions to improve the quality and consistency of the patents issued by the patent office. What I came to realize is if the USPTO has machine learning opportunities, so does every organization. The challenge is to identify those opportunities and to have a plan and team to implement them. However, that is often easier said than done.  At the USPTO, there was no way I could hire the talent — the data scientists or machine learning experts — that I have the privilege of working with today at Amazon. And that's what inspired me to lead the ML Solutions Lab at AWS.

As I mentioned earlier, we are a global team of data scientists and business consultants, who work side-by-side with our customers to identify their highest return-on-investment machine learning use cases and to help our customers implement them. What makes this fun and challenging is we do so through ideation sessions, hands-on-keyboard proofs of concepts to illustrate viability, and implementation to production. And we do so bringing learnings from 20 plus years of Amazon’s ML innovations in areas such as fulfillment and logistics, personalization and recommendations, computer vision, translation, fraud prevention, and forecasting and supply chain optimization.

Q. In your capacity as a leader, how do you view diversity?

Diversity in views and experiences is critical to innovation because, by definition, innovations require thinking outside of the box, finding a solution to an existing problem that no one has ever seen before. The broader the perspectives and experiences on the team, the greater the chances for that spark of innovation.

As a leader, I find that I make better decisions when team members challenge my thinking and offer contrary views. I welcome — in fact, I seek out — those contrary views, because the issues facing AI and ML require interdisciplinary approaches. No one person's going to have a complete view and perspective on all the issues relevant to AI and machine learning.

Q. What would you say to women considering a career in ML?

If that's your goal, pursue it with a passion. Don't wait for people who look like you to do what you know needs to be done. I have often been one of a few, or even the only woman, in the room or sitting at the table. Whether that was as a graduate student at the MIT AI Lab and the PhD program, or the first Asian American woman elected partner in my law firm, or the first woman appointed by the president of the United States to lead the United States Patent and Trademark Office. If I waited for people who looked like me to do what I did, I'd still be waiting.

That said, I am very encouraged to see the growing diversity within the field of AI and ML. We all have a long way to go still, but there are brilliant pioneers paving the way for future generations — and I look forward to seeing more in the future.

Research areas

Related content

US, WA, Seattle
Economists in this role partner with business stakeholders to distill complex problems into testable economic questions and generate actionable insights. They collaborate with engineers and scientists to estimate models on large-scale data, design pilots, measure impact, and scale successful prototypes into improved policies and programs. They leverage AI tools to scale economic study for broader business impact. They communicate findings to business leaders, incorporate feedback, and deliver customer-centric solutions at scale.
US, NY, New York
Are you passionate about solving big problems from ground-up? Do you enjoy building new state-of-the-art products at internet scale? Come lead the innovation in this startup team, vertical ad products. This is a green field problem without a known answer or a pattern to follow. We have ambitious vision to simplify full funnel advertising solutions, at scale, with specialized agentic AI-powered models and diversify the demand to strategic verticals including finserv, autos, locals.. etc. We are seeking an experienced Applied Scientist to drive innovation in our Ads Foundational Model. In this individual contributor role, you will apply advanced machine learning techniques to improve advertiser performance and customer experience. Key job responsibilities As an Applied Scientist on this team, you will: 1. Develop and drive the science strategy for Ads Foundational Model (Ads-FM), aligning it with the program's objectives and overall business goals. 2. Identify high-impact opportunities within Ads-FM program and lead the ideation, planning, and execution of science initiatives to address them. 3. Build and deploy machine learning models using computer vision, natural language processing, and deep learning to evaluate and enhance ad effectiveness. 4. Develop algorithms that extract meaningful signals from image, video, and audio content to predict and improve customer engagement 5. Leverage Amazon's extensive data repository to create predictive models that generate actionable recommendations for more compelling ad creative 6. Collaborate with business leaders and cross-functional teams to implement ML-powered solutions 7. Contribute to the ML roadmap for the Ads-FM program through innovation and research.
US, WA, Seattle
This role will contribute to developing the Economics and Science products and services in the Fee domain, with specialization in supply chain systems and fees. Through the lens of economics, you will develop causal links for how Amazon, Sellers and Customers interact. You will be a key and senior scientist, advising Amazon leaders how to price our services. You will work on developing frameworks and scaleable, repeatable models supporting optimal pricing and policy in the two-sided marketplace that is central to Amazon's business. The pricing for Amazon services is complex. You will partner with science and technology teams across Amazon including Advertising, Supply Chain, Operations, Prime, Consumer Pricing, and Finance. We are looking for an experienced Principal Economist to improve our understanding of seller Economics, enhance our ability to estimate the causal impact of fees, and work with partner teams to design pricing policy changes. In this role, you will provide guidance to scientists to develop econometric models to influence our fee pricing worldwide. You will lead the development of causal models to help isolate the impact of fee and policy changes from other business actions, using experiments when possible, or observational data when not. Key job responsibilities The ideal candidate will have extensive Economics knowledge, demonstrated strength in practical and policy relevant structural econometrics, strong collaboration skills, proven ability to lead highly ambiguous and large projects, and a drive to deliver results. They will work closely with Economists, Data / Applied Scientists, Strategy Analysts, Data Engineers, and Product leads to integrate economic insights into policy and systems production. Familiarity with systems and services that constitute seller supply chains is a plus but not required. About the team The Stores Economics and Sciences team is a central science team that supports Amazon's Retail and Supply Chain leadership. We tackle some of Amazon's most challenging economics and machine learning problems, where our mandate is to impact the business on massive scale.
US, CA, San Diego
The Private Brands team is looking for a Research Scientist to join the team in building science solutions at scale. Our team applies Optimization, Machine Learning, Statistics, Causal Inference, and Econometrics/Economics to derive actionable insights about the complex economy of Amazon’s retail business and develop Statistical Models and Algorithms to drive strategic business decisions and improve operations. We are an interdisciplinary team of Scientists, Engineers, and Economists. Key job responsibilities You will work with business leaders, scientists, and economists to translate business and functional requirements into concrete deliverables, including the design, development, testing, and deployment of highly scalable optimization solutions and ML models. This is a unique, high visibility opportunity for someone who wants to have business impact, dive deep into large-scale problems, enable measurable actions on the consumer economy, and work closely with scientists and economists. As a Research Scientist, you bring business and industry context to science and technology decisions. You set the standard for scientific excellence and make decisions that affect the way we build and integrate algorithms. Your solutions are exemplary in terms of algorithm design, clarity, model structure, efficiency, and extensibility. You tackle intrinsically hard problems, acquiring expertise as needed. You decompose complex problems into straightforward solutions. We are particularly interested in candidates with experience in Operations Research and predictive models and working with distributed systems. Academic and/or practical background in Operations Research, Machine Learning and Reinforcement Learning are particularly relevant for this position. To know more about Amazon science, Please visit https://www.amazon.science
US, CA, Palo Alto
Alexa for Shopping (previously Rufus) is seeking a Senior Manager, Applied Science to lead multidisciplinary teams of Applied Scientists and Machine Learning Engineers building next-generation conversational AI and multi-agent systems powering customer-facing experiences at scale. This leader will drive both scientific innovation and execution across large language models (LLMs), agent orchestration, retrieval and grounding systems, evaluation frameworks, and scalable AI infrastructure. The role requires a combination of deep technical judgment, organizational leadership, product and engineering partnership, and operational excellence. The ideal candidate has a strong track record of building high-performing science and engineering teams, translating ambiguous business problems into scalable AI solutions, and delivering measurable customer impact through applied machine learning and generative AI technologies. Key job responsibilities - Lead and grow teams of Applied Scientists and Machine Learning Engineers working on conversational AI and multi-agent orchestration systems. - Define and drive technical strategy for large-scale generative AI systems, including LLM routing, prompting, grounding, memory, tool use, personalization, and response optimization. - Partner closely with Product, Engineering, and Tech leadership to align AI investments with long-term business and customer goals. - Drive end-to-end delivery of production AI systems balancing quality, latency, scalability, safety, and operational reliability. - Establish scientific and engineering best practices across experimentation, evaluation, model iteration, and production deployment. - Lead roadmap prioritization and execution across research innovation and product delivery timelines. - Build scalable evaluation methodologies and quality frameworks for multilingual and global customer experiences. - Mentor and develop technical leaders across both science and engineering disciplines. - Foster a high-performance culture centered on customer obsession, innovation, operational excellence, and strong cross-functional collaboration.
US, NY, New York
We are seeking a Human-Robot Interaction (HRI) Applied Scientist to develop cutting-edge interactions that make robots feel alive, personal, and fun. In this role, you will focus on verbal and non-verbal conversational systems, social dynamics, memory, and long-term relationship formation between robots, their environments, and the people they interact with. Your contributions will be essential in advancing robotics by enabling expressive, socially intelligent, and trustworthy interactions between robots and humans. Key job responsibilities - Develop interactive systems that leverage large language models, multimodal inputs and outputs, reinforcement learning from human feedback, or other advanced techniques to achieve fluid, engaging, and socially appropriate robot behavior - Design and implement intelligent conversational systems that handle turn-taking, grounding, interruption, and incorporates context drawn from a robot's physical environment and shared history with a user - Integrate perceptual sensor streams including gaze, facial expression, gesture, posture, and more to understand social context and produce coherent, lifelike interactions. - Develop memory and personalization systems that allow robots to form lasting relationships with individual users, learn their environments, and adapt their behavior over weeks and months - Stay updated on advancements in HRI, NLP, multimodal AI, and cognitive and social science to apply cutting-edge techniques to robot interaction challenges - Lead technical projects from conception through production deployment - Mentor junior scientists and engineers - Bridge research initiatives with practical engineering implementation
IN, KA, Bengaluru
Do you want to join an innovative team of scientists applying machine learning and advanced statistical techniques to protect Amazon customers and enable a trusted eCommerce experience? Are you excited about modeling terabytes of data and building state-of-the-art algorithms to solve complex, real-world fraud and risk challenges? Do you enjoy owning end-to-end machine learning problems, directly influencing customer experience and company profitability, while collaborating in a diverse, high-performing team? If so, the Amazon Buyer Risk Prevention (BRP) Machine Learning team may be the right fit for you. We are seeking an Applied Scientist to design, develop, and deploy advanced algorithmic systems that safeguard millions of transactions every day. In this role, you will independently drive model development from problem formulation to production deployment, build scalable ML solutions, and leverage emerging technologies—including Generative AI and LLMs—to enhance fraud detection and next-generation risk prevention systems. Key job responsibilities Own end-to-end development of machine learning models for large-scale risk management systems Analyze large volumes of historical and real-time data to identify fraud patterns and emerging risk trends Design, develop, validate, and deploy innovative models to production environments Apply GenAI/LLM technologies to automate risk evaluation and improve operational efficiency Collaborate closely with software engineering teams to implement scalable, real-time model solutions Partner with operations and business stakeholders to translate risk insights into measurable impact Establish scalable and automated processes for data analysis, model experimentation, validation, and monitoring Track model performance and business metrics; communicate insights clearly to technical and non-technical stakeholders Research and implement novel machine learning and statistical methodologies
IN, KA, Bengaluru
Do you want to join an innovative team applying machine learning and advanced statistical techniques to protect Amazon customers and enable a trusted eCommerce experience? Are you excited about working with large-scale datasets and developing models that solve real-world fraud and risk challenges? If so, the Amazon Buyer Risk Prevention (BRP) Machine Learning team may be the right fit for you. We are seeking an Applied Scientist to help develop scalable machine learning solutions that safeguard millions of transactions every day. In this role, you will partner with senior scientists and engineers to translate business problems into data-driven solutions, build and evaluate models, and contribute to next-generation risk prevention systems, including applications of Generative AI and LLM technologies. Key job responsibilities Apply machine learning and statistical techniques to build and improve risk management models Analyze large-scale historical data to identify risk patterns and emerging trends Develop, validate, and deploy innovative models under the guidance of senior scientists Experiment with emerging technologies, including GenAI/LLMs, to enhance automation and risk evaluation Collaborate closely with software engineers to implement models in real-time production systems Partner with operations and business teams to improve risk policies and operational efficiency Build scalable, automated pipelines for data analysis, model training, and validation Monitor model performance and provide clear reporting on key risk and business metrics Research and prototype new modeling approaches to improve system performance
IN, KA, Bengaluru
Do you want to join an innovative team of scientists applying machine learning and advanced statistical techniques to protect Amazon customers and enable a trusted eCommerce experience? Are you excited about modeling terabytes of data and building state-of-the-art algorithms to solve complex, real-world fraud and risk challenges? Do you enjoy owning end-to-end machine learning problems, directly influencing customer experience and company profitability, while collaborating in a diverse, high-performing team? If so, the Amazon Buyer Risk Prevention (BRP) Machine Learning team may be the right fit for you. We are seeking an Applied Scientist to design, develop, and deploy advanced algorithmic systems that safeguard millions of transactions every day. In this role, you will independently drive model development from problem formulation to production deployment, build scalable ML solutions, and leverage emerging technologies—including Generative AI and LLMs—to enhance fraud detection and next-generation risk prevention systems. Key job responsibilities Own end-to-end development of machine learning models for large-scale risk management systems Analyze large volumes of historical and real-time data to identify fraud patterns and emerging risk trends Design, develop, validate, and deploy innovative models to production environments Apply GenAI/LLM technologies to automate risk evaluation and improve operational efficiency Collaborate closely with software engineering teams to implement scalable, real-time model solutions Partner with operations and business stakeholders to translate risk insights into measurable impact Establish scalable and automated processes for data analysis, model experimentation, validation, and monitoring Track model performance and business metrics; communicate insights clearly to technical and non-technical stakeholders Research and implement novel machine learning and statistical methodologies
IN, KA, Bengaluru
Do you want to lead the development of advanced machine learning systems that protect millions of customers and power a trusted global eCommerce experience? Are you passionate about modeling terabytes of data, solving highly ambiguous fraud and risk challenges, and driving step-change improvements through scientific innovation? If so, the Amazon Buyer Risk Prevention (BRP) Machine Learning team may be the right place for you. We are seeking a Senior Applied Scientist to define and drive the scientific direction of large-scale risk management systems that safeguard millions of transactions every day. In this role, you will lead the design and deployment of advanced machine learning solutions, influence cross-team technical strategy, and leverage emerging technologies—including Generative AI and LLMs—to build next-generation risk prevention platforms. Key job responsibilities Lead the end-to-end scientific strategy for large-scale fraud and risk modeling initiatives Define problem statements, success metrics, and long-term modeling roadmaps in partnership with business and engineering leaders Design, develop, and deploy highly scalable machine learning systems in real-time production environments Drive innovation using advanced ML, deep learning, and GenAI/LLM technologies to automate and transform risk evaluation Influence system architecture and partner with engineering teams to ensure robust, scalable implementations Establish best practices for experimentation, model validation, monitoring, and lifecycle management Mentor and raise the technical bar for junior scientists through reviews, technical guidance, and thought leadership Communicate complex scientific insights clearly to senior leadership and cross-functional stakeholders Identify emerging scientific trends and translate them into impactful production solutions