Sequence of nucleotide bases in DNA
For the first time, the largest genomic sequencing repository in the Americas will be natively accessible on AWS through the Open Data Sponsorship Program.
Credit: sergunt

AWS democratizes access to the largest genomic sequences repository — NIH’s Sequence Read Archive

For the first time, the largest genomic sequencing repository in the Americas will be natively accessible on AWS through the Open Data Sponsorship Program.

Amazon today announced that the National Institutes of Health (NIH) Sequence Read Archive (SRA) data, managed by the National Library of Medicine’s (NLM) National Center for Biotechnology Information (NCBI), will now be freely accessible through its AWS Open Data Sponsorship program.

In 2018, NCBI began the migration of SRA data to AWS’ cloud platform by leveraging the NIH STRIDES Initiative. With SRA publicly accessible on Amazon Simple Storage Service (Amazon S3), scientists can now seamlessly integrate SRA data into cloud-based genomics workflows. Scientists can choose to access the data via native AWS clients such as the AWS Management Console or the AWS Command Line Interface (AWS CLI), or use open-source tools such as the SRA Explorer.

“By making SRA data available in the cloud, researchers in the life sciences and genomics community can build on a strong foundation of open data and pay it forward with tools, solutions, and products that enrich and expand the science ecosystem,” says Dave Levy, AWS vice president for U.S. government, nonprofit and healthcare businesses.

Susan Gregurick
Susan Gregurick, PhD, NIH associate director for data science, and director, Office of Data Science Strategy.
Credit: NIH

“The ability to access SRA data in the cloud is a wonderful realization of NIH's long-standing principles for broad, rapid, and equitable public access to biomedical research data. The new opportunities for computational access afforded by this open data program will accelerate the pace of research, permit us to ask bold questions, and enable scientific discoveries,” says Susan Gregurick, PhD, NIH associate director for data science and director, Office of Data Science Strategy.

Since its discovery in the 1860s, DNA has been a source of fascination and revelation. Through genomics, the field dedicated to the study of DNA, scientists have begun to understand how DNA can dictate an individual’s appearance, behavior, and disease risk. In fact, common conditions such as diabetes, depression, and cancer all have known genetic contributions.

The reuse of genetic data is encouraged within the science community to reduce the overall cost of data generation and ensure that discoveries can be replicated by other scientists. Major research funding agencies, such as the NIH, the Howard Hughes Medical Institute, and the Department of Defense, recommend a few repositories to store genomic data so that it can be accessed and reused by others. SRA is one of these recommended repositories and is one of the oldest repositories designed specifically for next-generation biomedical/genomic sequencing data.

The fundamental unit of DNA is the nucleotide, which in genomics is denoted by its nitrogenous base — the familiar A, C, T, or G. SRA currently stores more than 44 petabases of genomic sequence today. For perspective, this amount of data is over 6 billion human genomes—more than 18 times the current population of the United States.

SRA currently measures more than 40 petabytes in volume, and there is no sign of slowing down. In fact, experts predict that the SRA will double in volume every 12 to 18 months for the foreseeable future.

“Object-based storage like Amazon S3 can scale with that rate of growth,” says Levy, “and with the power of the cloud, so can the compute.”

SRA comprises genomic sequences from all branches of the tree of life and has proven essential in the fight against COVID 19. For example, Serratus, an open science viral discovery platform stemming from the University of British Columbia’s Cloud Innovation Center, aligned coronavirus pangenomes to 3.8 million SRA submissions using AWS to identify new coronavirus sequences in the battle against COVID-19 (learn more about how AWS is helping the fight against COVID-19).

To stay up to date on the Sequence Read Archive, visit ncbi.nlm.nih.gov/sra. Learn more about Open Data on AWS at opendata.aws.

Related content

US, CA, Palo Alto
The Amazon Search team creates powerful, customer-focused search and advertising solutions and technologies. Whenever a customer visits an Amazon site worldwide and types in a query or browses through product categories, the Amazon Search services go to work. We design, develop, and deploy high performance, fault-tolerant distributed search systems used by millions of Amazon customers every day. Our team works to maximize the quality and effectiveness of the search experience for visitors to Amazon websites worldwide.
JP, Tokyo
The Amazon Logistics (AMZL) Team is responsible for the acquisition, design, construction, and management of all facilities in the Amazon Delivery Station Network. AMZL is looking for a talented and passionate Data Scientist to help shape its Last Mile business with technical strategies and solutions, by processing, analyzing and interpreting huge data sets. You should be comfortable with ambiguity, problem solving and enjoy working in a fast-paced, diverse and dynamic environment. Using analytical rigor and statistical methods, you mine through data to identify opportunities for Amazon and our delivery channels. And you collaborate with other scientists, engineers, Product and Program Managers to deploy new products and solutions. [More Information] Last Mile Department Data Analyst/BI Engineer Tokyo Office *Amazon is committed to a diverse and inclusive workplace. Amazon is an equal opportunity employer and does not discriminate on the basis of race, national origin, gender, gender identity, sexual orientation, protected veteran status, disability, age, or other legally protected status. For individuals with disabilities who would like to request an accommodation, visit https://www.amazon.jobs/disability/jp Key job responsibilities Creating a roadmap of the most challenging business questions and use data to articulate possible root cause analysis and solutions Managing and executing entire projects or components of large projects from start to finish including project management, data gathering and manipulation, synthesis and modeling, problem solving, and communication of insights Partnering with Product, Program and Engineering teams to design and run models, research new algorithms, and prove incrementality and drive growth Understanding drivers, impacts, and key influences on seller growth dynamics Developing and scaling end-to-end ML Models and solutions Automating feedback loops for algorithms in production Utilizing Amazon systems and tools to effectively work with terabytes of data About the team Last Mile Execution Analytics (LMEA) team of JP works as an integral part of Amazon Logistics to ensure that its business intelligence, analytics, tools and planning needs are met. By providing information, insight, and decision support, we strive to enable success of all parts of AMZL. Our customer set includes senior management, station operations, external vendors, long-term planning, Ops technology (Voice of the Delivery Station, Voice of the Customer), network planning, and pretty much every BI and Ops teams. Voice of Employee [Work Life Harmony] We believe, it is important to spend private time such as spending time with your family or doing anything you like to spur innovation. Amazon promotes a fulfilling and flexible work style according to the work volume and lifestyle of each employee.
US, CA, San Francisco
About Twitch Launched in 2011, Twitch is a global community that comes together each day to create multiplayer entertainment: unique, live, unpredictable experiences created by the interactions of millions. We bring the joy of co-op to everything, from casual gaming to world-class esports to anime marathons, music, and art streams. Twitch also hosts TwitchCon, where we bring everyone together to celebrate, learn, and grow their personal interests and passions. We’re always live at Twitch. Stay up to date on all things Twitch on Linkedin, Twitter and on our Blog. About the role: Twitch builds data-driven machine learning solutions across several rich problem spaces: Natural Language Processing (NLP), Recommendations, Semantic Search, Classification/Categorization, Anomaly Detection, Forecasting, Safety, and HCI/Social Computing/Computational Social Science. As an Intern, you will work with a dedicated Mentor and Manager on a project in one of these problem areas. You will also be supported by an Advisor and participate in cohort activities such as research teach backs and leadership talks. This position can also be located in San Francisco, CA or virtual. You Will: Solve large-scale data problems. Design solutions for Twitch's problem spaces Explore ML and data research
US, CA, San Francisco
About Twitch Launched in 2011, Twitch is a global community that comes together each day to create multiplayer entertainment: unique, live, unpredictable experiences created by the interactions of millions. We bring the joy of co-op to everything, from casual gaming to world-class esports to anime marathons, music, and art streams. Twitch also hosts TwitchCon, where we bring everyone together to celebrate, learn, and grow their personal interests and passions. We’re always live at Twitch. Stay up to date on all things Twitch on Linkedin, Twitter and on our Blog. About the role: Twitch builds data-driven machine learning solutions across several rich problem spaces: Natural Language Processing (NLP), Recommendations, Semantic Search, Classification/Categorization, Anomaly Detection, Forecasting, Safety, and HCI/Social Computing/Computational Social Science. As an Intern, you will work with a dedicated Mentor and Manager on a project in one of these problem areas. You will also be supported by an Advisor and participate in cohort activities such as research teach backs and leadership talks. This position can also be located in San Francisco, CA or virtual. You Will: Solve large-scale data problems. Design solutions for Twitch's problem spaces Explore ML and data research
LU, Luxembourg
Are you a talented and inventive scientist with a strong passion about modern data technologies and interested to improve business processes, extracting value from the data? Would you like to be a part of an organization that is aiming to use self-learning technology to process data in order to support the management of the procurement function? The Global Procurement Technology, as a part of Global Procurement Operations, is seeking a skilled Data Scientist to help build its future data intelligence in business ecosystem, working with large distributed systems of data and providing Machine Learning (ML) and Predictive Modeling expertise. You will be a member of the Data Engineering and ML Team, joining a fast-growing global organization, with a great vision to transform the Procurement field, and become the role model in the market. This team plays a strategic role supporting the core Procurement business domains as well as it is the cornerstone of any transformation and innovation initiative. Our mission is to provide a high-quality data environment to facilitate process optimization and business digitalization, on a global scale. We are supporting business initiatives, including but not limited to, strategic supplier sourcing (e.g. contracting, negotiation, spend analysis, market research, etc.), order management, supplier performance, etc. We are seeking an individual who can thrive in a fast-paced work environment, be collaborative and share knowledge and experience with his colleagues. You are expected to deliver results, but at the same time have fun with your teammates and enjoy working in the company. In Amazon, you will find all the resources required to learn new skills, grow your career, and become a better professional. You will connect with world leaders in your field and you will be tackling Data Science challenges to ensure business continuity, by taking the right decisions for your customers. As a Data Scientist in the team, you will: -be the subject matter expert to support team strategies that will take Global Procurement Operations towards world-class predictive maintenance practices and processes, driving more effective procurement functions, e.g. supplier segmentation, negotiations, shipping supplies volume forecast, spend management, etc. -have strong analytical skills and excel in the design, creation, management, and enterprise use of large data sets, combining raw data from different sources -provide technical expertise to support the development of ML models to facilitate intelligent digital services, such as Contract Lifecycle Management (CLM) and Negotiations platform -cooperate closely with different groups of stakeholders, e.g. data/software engineers, product/program managers, analysts, senior leadership, etc. to evaluate business needs and objectives to set up the best data management environment -create and share with audiences of varying levels technical papers and presentations -deal with ambiguity, prioritizing needs, and delivering results in a dynamic environment Basic qualifications -Master’s Degree in Computer Science/Engineering, Informatics, Mathematics, or a related technical discipline -3+ years of industry experience in data engineering/science, business intelligence or related field -3+ years experience in algorithm design, engineering and implementation for very-large scale applications to solve real problems -Very good knowledge of data modeling and evaluation -Very good understanding of regression modeling, forecasting techniques, time series analysis, machine-learning concepts such as supervised and unsupervised learning, classification, random forest, etc. -SQL and query performance tuning skills Preferred qualifications -2+ years of proficiency in using R, Python, Scala, Java or any modern language for data processing and statistical analysis -Experience with various RDBMS, such as PostgreSQL, MS SQL Server, MySQL, etc. -Experience architecting Big Data and ML solutions with AWS products (Redshift, DynamoDB, Lambda, S3, EMR, SageMaker, Lex, Kendra, Forecast etc.) -Experience articulating business questions and using quantitative techniques to arrive at a solution using available data -Experience with agile/scrum methodologies and its benefits of managing projects efficiently and delivering results iteratively -Excellent written and verbal communication skills including data visualization, especially in regards to quantitative topics discussed with non-technical colleagues
US, CA, San Francisco
About Twitch Launched in 2011, Twitch is a global community that comes together each day to create multiplayer entertainment: unique, live, unpredictable experiences created by the interactions of millions. We bring the joy of co-op to everything, from casual gaming to world-class esports to anime marathons, music, and art streams. Twitch also hosts TwitchCon, where we bring everyone together to celebrate, learn, and grow their personal interests and passions. We’re always live at Twitch. Stay up to date on all things Twitch on Linkedin, Twitter and on our Blog. About the role: Twitch builds data-driven machine learning solutions across several rich problem spaces: Natural Language Processing (NLP), Recommendations, Semantic Search, Classification/Categorization, Anomaly Detection, Forecasting, Safety, and HCI/Social Computing/Computational Social Science. As an Intern, you will work with a dedicated Mentor and Manager on a project in one of these problem areas. You will also be supported by an Advisor and participate in cohort activities such as research teach backs and leadership talks. This position can also be located in San Francisco, CA or virtual. You Will: Solve large-scale data problems. Design solutions for Twitch's problem spaces Explore ML and data research
US, CA, San Francisco
About Twitch Launched in 2011, Twitch is a global community that comes together each day to create multiplayer entertainment: unique, live, unpredictable experiences created by the interactions of millions. We bring the joy of co-op to everything, from casual gaming to world-class esports to anime marathons, music, and art streams. Twitch also hosts TwitchCon, where we bring everyone together to celebrate, learn, and grow their personal interests and passions. We’re always live at Twitch. Stay up to date on all things Twitch on Linkedin, Twitter and on our Blog. About the role: Twitch builds data-driven machine learning solutions across several rich problem spaces: Natural Language Processing (NLP), Recommendations, Semantic Search, Classification/Categorization, Anomaly Detection, Forecasting, Safety, and HCI/Social Computing/Computational Social Science. As an Intern, you will work with a dedicated Mentor and Manager on a project in one of these problem areas. You will also be supported by an Advisor and participate in cohort activities such as research teach backs and leadership talks. This position can also be located in San Francisco, CA or virtual. You Will: Solve large-scale data problems. Design solutions for Twitch's problem spaces Explore ML and data research
US, CA, San Francisco
About Twitch Launched in 2011, Twitch is a global community that comes together each day to create multiplayer entertainment: unique, live, unpredictable experiences created by the interactions of millions. We bring the joy of co-op to everything, from casual gaming to world-class esports to anime marathons, music, and art streams. Twitch also hosts TwitchCon, where we bring everyone together to celebrate, learn, and grow their personal interests and passions. We’re always live at Twitch. Stay up to date on all things Twitch on Linkedin, Twitter and on our Blog. About the role: Twitch builds data-driven machine learning solutions across several rich problem spaces: Natural Language Processing (NLP), Recommendations, Semantic Search, Classification/Categorization, Anomaly Detection, Forecasting, Safety, and HCI/Social Computing/Computational Social Science. As an Intern, you will work with a dedicated Mentor and Manager on a project in one of these problem areas. You will also be supported by an Advisor and participate in cohort activities such as research teach backs and leadership talks. This position can also be located in San Francisco, CA or virtual. You Will: Solve large-scale data problems. Design solutions for Twitch's problem spaces Explore ML and data research
US, CA, San Francisco
About Twitch Launched in 2011, Twitch is a global community that comes together each day to create multiplayer entertainment: unique, live, unpredictable experiences created by the interactions of millions. We bring the joy of co-op to everything, from casual gaming to world-class esports to anime marathons, music, and art streams. Twitch also hosts TwitchCon, where we bring everyone together to celebrate, learn, and grow their personal interests and passions. We’re always live at Twitch. Stay up to date on all things Twitch on Linkedin, Twitter and on our Blog. About the role: Twitch builds data-driven machine learning solutions across several rich problem spaces: Natural Language Processing (NLP), Recommendations, Semantic Search, Classification/Categorization, Anomaly Detection, Forecasting, Safety, and HCI/Social Computing/Computational Social Science. As an Intern, you will work with a dedicated Mentor and Manager on a project in one of these problem areas. You will also be supported by an Advisor and participate in cohort activities such as research teach backs and leadership talks. This position can also be located in San Francisco, CA or virtual. You Will: Solve large-scale data problems. Design solutions for Twitch's problem spaces Explore ML and data research
US, WA, Seattle
We are a team of doers working passionately to apply cutting-edge advances in deep learning in the life sciences to solve real-world problems. As a Senior Applied Science Manager you will participate in developing exciting products for customers. Our team rewards curiosity while maintaining a laser-focus in bringing products to market. Competitive candidates are responsive, flexible, and able to succeed within an open, collaborative, entrepreneurial, startup-like environment. At the leading edge of both academic and applied research in this product area, you have the opportunity to work together with a diverse and talented team of scientists, engineers, and product managers and collaborate with others teams. Location is in Seattle, US Embrace Diversity Here at Amazon, we embrace our differences. We are committed to furthering our culture of inclusion. We have ten employee-led affinity groups, reaching 40,000 employees in over 190 chapters globally. We have innovative benefit offerings, and host annual and ongoing learning experiences, including our Conversations on Race and Ethnicity (CORE) and AmazeCon (gender diversity) conferences. Amazon’s culture of inclusion is reinforced within our 14 Leadership Principles, which remind team members to seek diverse perspectives, learn and be curious, and earn trust Balance Work and Life Our team puts a high value on work-life balance. It isn’t about how many hours you spend at home or at work; it’s about the flow you establish that brings energy to both parts of your life. We believe striking the right balance between your personal and professional life is critical to life-long happiness and fulfillment. We offer flexibility in working hours and encourage you to find your own balance between your work and personal lives Mentor & Grow Careers Our team is dedicated to supporting new members. We have a broad mix of experience levels and tenures, and we’re building an environment that celebrates knowledge sharing and mentorship. Our senior members enjoy one-on-one mentoring and thorough, but kind, code reviews. We care about your career growth and strive to assign projects based on what will help each team member develop into a better-rounded engineer and enable them to take on more complex tasks in the future. Key job responsibilities • Manage high performing engineering and science teams • Hire and develop top-performing engineers, scientists, and other managers • Develop and execute on project plans and delivery commitments • Work with business, data science, software engineer, biological, and product leaders to help define product requirements and with managers, scientists, and engineers to execute on them • Build and maintain world-class customer experience and operational excellence for your deliverables