George Michailidis paper abstract.jpg
Sequential change-point detection in high-dimensional Gaussian graphic models”, published by Hossein Keshavarz, a senior data scientist at relationalAI; George Michailidis; and Yves Atchadé, a professor of statistics at Boston University, touches on the theme of anomaly detection.

George Michailidis: How to identify important changes in online networks

Amazon Scholar discusses the evolution of anomaly detection research.

As the director of the University of Florida Informatics Institute, George Michailidis, who is also an Amazon Scholar on the Supply Chain Optimization Technologies (SCOT) team, leads a diverse community of data scientists with training in engineering, statistics, applied math, and other sciences. He notes that assortment of backgrounds is important in data science.

George Michailidis is the director of the University of Florida Informatics Institute, and an Amazon Scholar on the Supply Chain Optimization Technologies team.
George Michailidis is the director of the University of Florida Informatics Institute, and an Amazon Scholar on the Supply Chain Optimization Technologies team.

“In addition to statistics, there are a number of other disciplines that data scientists need to be aware of, such as programming, algorithms, optimization, and of course, some subject matter expertise because you don't do data science in a vacuum,” he says.

Michailidis was trained in applied mathematics and statistics, with a PhD thesis focused on optimization problems and its applications to statistical problems. His postdoc was in operations research, which introduced him to a different class of problems. “Some of them come about in Amazon’s supply chain, for example, such as problems of how to schedule the jobs on the machine, or how to route the traffic in the network, and so forth.”

For about 17 years, Michailidis was a faculty member at the University of Michigan in statistics with a joint appointment in electrical engineering. “I combined my statistical training with my interest in engineering types of problems.”

Data integration

Since then, his research agenda at the University of Florida has had strong theoretical components, but he remains very interested in practical applications. One of his current interests is data integration, and its many potential uses. For example, when it comes to the study of diseases, there is a wealth of molecular-level data from patients’ samples. At the same time, there is information on the patient's clinical records and demographics.

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“How do you create models to try to identify key drivers, for example, for disease progression by combining all these different data sources,” is one of the questions that motivates Michailidis’ work. With these models, he tries to provide insights both for prognostic or diagnostic purposes, but also for the understanding of the biological mechanisms that lead to that disease.

Another large component of Michailidis’ research relates to a problem known as anomaly detection. “This is an old problem that has been going on for more than 60 years,” he says. To a large extent, it originated in manufacturing, where people were interested in finding defects in the manufacturing process and fixing them. As the technology evolved, similar questions have been arising in many other fields.

This is broadly the theme of a paper published by Michailidis and his colleagues Hossein Keshavarz, a senior data scientist at relationalAI, and Yves Atchadé, a professor of statistics at Boston University, entitled “Sequential change-point detection in high-dimensional Gaussian graphic models.”

Michailidis notes that, as manufacturing processes became more complex, it became necessary to monitor many more metrics.

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“A typical example of this complexity is semiconductor manufacturing, where you have to monitor hundreds of little things,” he says.

In more modern applications, the next step is to monitor networks.

“You’re not only monitoring a lot of things. Now these things are interconnected and you're trying to understand how this network, as an object, changes its structure at some point in time,” Michailidis explains. “And you're doing that in an online fashion because this process keeps going. You keep observing the network and you're trying to identify changes as quickly as possible.”

In addition to developing a technique to detect changes, researchers also must establish that their technique is sensitive enough for certain types of changes and determine whether it detects them quickly enough. This is the challenge, in the online realm, that Michailidis and his colleagues attempt to address in their paper. The paper introduces “introduces a novel scalable online algorithm for detecting an unknown number of abrupt changes”.

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In the paper, the authors present an application on stock market data, where the network is made of movements of stocks. “We showed how the network changes, for example, during the great financial crisis of 2008, and how the stock market got affected by the European debt crisis in 2012 and so forth.” Michailidis notes that these techniques are especially suited for problems where there are dependencies between observable elements without knowledge of the nature of those dependencies.

“With stocks, whether they are moving together or in different directions, these movements —or lack of movement — is what gives rise to the network structure. And that’s what we are capturing with these graphical models,” he says.

Within the SCOT organization, Michailidis says he has the opportunity to tackle challenging problems at an unprecedented scale. “The problems are much more complex because they're not as clear cut as they are in academia.” In this interview, he discusses his research on anomaly detection and its potential applications.

  1. Q. 

    Your paper mentions high dimensional piecewise sparse graphical models. What does that entail and what are some applications?

    A. 

    The graphical model is a particular statistical model that tries to capture statistical dependencies between the things that are measured on the nodes. In the stock market example, you're looking at the rate of return of a stock. This is the measurement that you have on every node over time and you're trying to understand, for example, whether the return of one technology stock is correlated with the return of some other technology stock. So that's what the graphical model is trying to capture — the statistical dependencies.

    The next step is what we mean by high dimensional. Essentially, it means that the number of nodes, or variables, in your network becomes very large compared to how many observations you have. You may have a short observation period, but with a high number of nodes. What we call high-dimensional statistics became a big field of study 15 to 20 years ago, with a lot of applications. The reason is that, in more classical statistics, we always made the assumption that the sample size in our observations is much larger than the number of variables. In the high-dimensional regime, the relationship flips and you have many more variables than observations and that poses a whole bunch of technical challenges, to the point where you can’t even solve the problem.

    So, you need some additional assumptions, and that's where another important term comes in: sparse. This means that this network doesn't have too many connections. If it was very well connected, then we would not be able to solve the problem for technical reasons, because you would not have enough data. So, you make the assumption that these networks are not too connected to compensate for how much data you have.

    And the last term we need to understand is piecewise. By piecewise, we mean that, for this period, the network structure stays the same, and then changes abruptly to some other structure. It's not a gradual change — although this may be happening in reality. It heavily depends on the underlying application. It may either be a simplifying assumption in order to do the analysis or, in many cases, that's exactly what happens.

    In the neuroscience example, if the subject sits in the scanner without moving, and then you tell them — “raise your hand or read this sentence” — there is an abrupt change because there is a new task after a resting state. This is also possible in the stock market, where new information may create these abrupt changes.

    In many applications, there is really an abrupt change and this is the proper setting to use. In some other cases, changes may be a little bit more gradual. But we can still look at them as abrupt changes because it becomes a good working hypothesis and simplifies things. A lot of these techniques that people develop are good working models, and not exactly what's going on, that's fairly standard in a lot of scientific fields. And that explains the high dimensional piecewise sparse graphical model. That's where all the pieces come together.

  2. Q. 

    Why is it important to be able to detect these abrupt changes in an online setting?

    A. 

    Because you keep collecting the data, and you would like to identify these changes as things evolve. You could solve the same problem, with the same high dimensional sparse piecewise graphical model, in an offline manner. In that case, the difference is that you have already collected these data and would like to explore them in a retrospective manner to see if you can find these types of changes. That's also a problem of interest.

    The reason that in this article we focus on online detection is that we have already done work on the offline version, so it was natural to start exploring what is different in an online setting. And it's much, much more challenging, because you don't know the future and you keep getting new information, and you're trying to detect these changes quickly. Online problems in machine learning and other areas are more challenging than offline problems, as a general rule. So, this is for me a natural evolution, since I’ve already used these sparse graphical models in an offline setting.

  3. Q. 

    What does the paper demonstrate and how is it applicable to Amazon?

    A. 

    The paper does demonstrate that it is possible to detect these changes online, so it’s a positive message. And it also shows a caveat. If, for example, the changes in this connectivity pattern were concentrated on only one node, then we could not detect them with the current technology. Because that's a very localized change, it only involves a very tiny part of the network. And our technique would only be able to detect them by waiting for a very long time. From an applications perspective, that makes it uninteresting. That tells you the limitations, which are important in some settings. We have done most of the work, but we found out that we were missing something. So, we need to go and develop a little bit more.

    The results could be applicable to Amazon because these graphical models come up a lot. So far, we have used techniques where we haven't taken the connections into account, we have just looked simply at what is going on in the time series, let's say, of a single node and whether that changes. Obviously, given the fact that Amazon operates in a highly volatile environment, changes are important. In the longer term, given the fact that the team has done work with graphical models, it may be interesting to utilize some of these techniques. The potential is there.

    In general, anomaly detection work to date across many disciplines (statistics, signal processing, machine learning, econometrics) has largely focused on parametric models, where with some effort the theoretical properties of anomaly detection procedures can be elucidated analytically and then validated through simulations. The analytical work provides deeper insights into the performance of these anomaly detection procedures and their limitations, and when they do not perform well. With all the advances in deep learning models, they become prime tools to use in anomaly detection problems.

    However, the challenge then becomes, to understand the performance limits of such models, beyond relying on numerical work. Such advances may take some time, but once the community makes progress, much more powerful procedures will be available to the practitioners.

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As a Senior Applied Scientist in the Alexa AI team, you will define and drive the science roadmap for state-of-the-art conversational AI systems powered by large language models, directly impacting how millions of customers interact with Alexa daily. You'll lead the design of LLM fine-tuning, alignment, and agentic architectures that operate reliably at scale, owning end-to-end delivery from research formulation through production deployment. Working at the intersection of research and production, you'll translate state of the art advances into customer-facing features. Your work will span the full ML lifecycle: developing novel evaluation frameworks, building automated training pipelines, and conducting rigorous experimentation across diverse devices and endpoints. Collaborating with engineering, product, and cross-functional science teams across Amazon, you'll tackle the team's most complex technical challenges while maintaining practical focus on customer value. This role offers the opportunity to publish at top-tier conferences, generate intellectual property, and see your innovations scale to one of the world's most popular voice assistants. Key job responsibilities As a Senior Applied Scientist in the Alexa AI team: - Define and drive the science roadmap for conversational AI capabilities powered by large language models - Design, implement, and evaluate novel approaches to LLM fine-tuning, alignment (RLHF, DPO), and distillation for production deployment - Architect agentic systems (multi-step reasoning, tool use, planning, and orchestration) that work reliably at scale - Develop evaluation frameworks and methodologies that go beyond standard benchmarks to capture real-world conversational quality - Translate research advances into customer-facing products, working closely with engineering, product, and cross-functional science teams - Own end-to-end delivery of complex, ambiguous research initiatives from problem formulation through experimentation to production deployment, with minimal guidance - Tackle the team's most complex technical problems while maintaining practical focus on customer value and solution generalizability - Advance the team's scientific reputation through high-impact publications and presentations at top-tier internal and external venues, and generate intellectual property through patents The applicable collective agreement for this role is CBA for employees of Telecommunication Sector. The position is classified at level 6 or above, depending on the candidate’s skills, competences and experience. The minimum gross annual base salary for this position is listed below. The base salary listed corresponds to working on a full-time basis. For part-time hours, the salary will be pro-rated. Amazon reserves the right to offer a higher salary and/or level, depending on the candidate's skills, competencies, and experience. Amazon's package may include a sign on payment. In addition, the candidate may be eligible to participate in a restricted stock unit scheme operated independently by Amazon.com Inc. in USA. Your recruiting team will share final salary and any restricted stock unit scheme if applicable, depending on skills and requirements. In addition to statutory benefits, and those applicable to the relevant CBA, company supplementary benefits may apply subject to further terms. Italy- EUR104,500 gross annually. A day in the life As a Senior Applied Scientist in the Alexa AI team, your day will involve leading cross-functional collaborations with engineering, product, and science teams to define the technical direction for our conversational assistant. You'll design experiments that shape the science roadmap, mentor junior scientists, and make high-judgment calls on architecture and deployment trade-offs. Working in a fast-paced, ambiguous environment, you'll own end-to-end delivery of complex initiatives: from formulating novel research problems to presenting strategic recommendations to senior leadership. Your ability to influence across organizational boundaries will drive measurable customer impact while raising the bar for millions of customers. About the team Alexa AI is building the science and technology behind Alexa+, Amazon's next-generation conversational assistant. Our team works at the intersection of large language models, reinforcement learning from human feedback and verifiable rewards, agentic architectures, and multilingual/multimodal understanding. We operate at massive scale: our models serve customers across dozens of languages and device types. If you want to push the frontier of conversational AI and see your work used by people every day, come join us.
US, WA, Bellevue
The Supply Chain Optimization Technologies (SCOT) team builds technology to automate and optimize Amazon’s supply chain of physical goods. We seek a Data Scientist with strong analytical and communication skills to join our team. SCOT manages Amazon's inventory under uncertainty of demand, pricing, promotions, supply, vendor lead times, and product life cycle. We optimize complex trade-offs between customer experience, inventory costs, fulfillment costs, fulfillment center capacity, etc. We develop sophisticated algorithms that involve learning from large amounts of data such as prices, promotions, similar products, and other data from our product catalog in order to automatically act on millions of dollars’ worth of inventory weekly and establish plans for tens of thousands of employees. As a Data Scientist, you will contribute to the research community, by working with other scientists across Amazon and our Supply Chain, as well as collaborating with academic researchers and publishing papers both internally and externally. Key job responsibilities Major responsibilities include: - Analysis of large amounts of data from different parts of the supply chain and their associated business functions - Improving upon existing machine learning methodologies by developing new data sources, developing and testing model enhancements, running computational experiments, and fine-tuning model parameters for new models - Formalizing assumptions about how models are expected to behave, creating definitions of outliers, developing methods to systematically identify these outliers, and explaining why they are reasonable or identifying fixes for them - Communicating verbally and in writing to business customers with various levels of technical knowledge, educating them about our research, as well as sharing insights and recommendations - Utilizing code (Python, R, Scala, etc.) for analyzing data and building statistical and machine learning models and algorithms A day in the life As a Data Scientist in SCOT, you will be tasked to understand and work with innovative research tools to enable the implementation of sophisticated models on big data. As a successful data scientist in the SCOT team, you are an analytical problem solver who enjoys diving into data from various businesses, is excited about investigations and algorithms, can multi-task, and can credibly interface between scientists, engineers and business stakeholders. Your expertise in synthesizing and communicating insights and recommendations to audiences of varying levels of technical sophistication will enable you to answer specific business questions and innovate for the future. Amazon offers a full range of benefits that support you and eligible family members, including domestic partners and their children. Benefits can vary by location, the number of regularly scheduled hours you work, length of employment, and job status such as seasonal or temporary employment. The benefits that generally apply to regular, full-time employees include: - Medical, Dental, and Vision Coverage - Maternity and Parental Leave Options - Paid Time Off (PTO) - 401(k) Plan If you are not sure that every qualification on the list above describes you exactly, we'd still love to hear from you! At Amazon, we value people with unique backgrounds, experiences, and skillsets. If you’re passionate about this role and want to make an impact on a global scale, please apply!