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3 important themes from Amazon's 2019 NeurIPS papers

Time series forecasting, bandit problems, and optimization are integral to Amazon's efforts to deliver better value for its customers.

Last year, the first 2,000-2,500 publicly released tickets to the Conference on Neural Information Processing Systems, or NeurIPS, sold out in 12 minutes.

This year, the conference organizers moved to a lottery system, allowing aspiring attendees to register in advance and randomly selecting invitees from the pool of registrants. But they also bumped the number of public-release tickets up from around 2,000 to 3,500, testifying to the conference’s continued popularity.

At NeurIPS this year, there are 26 papers with Amazon coauthors. They cover a wide range of topics, but surveying their titles, Alex Smola, a vice president and distinguished scientist in the Amazon Web Services organization, discerns three prominent themes, all tied to Amazon’s efforts to deliver better value for its customers.

Those three themes are time series forecasting (and causality), bandit problems, and optimization.

1. Time series forecasting

Time series forecasting involves measuring some quantity over time — such as the number of deliveries in a particular region in the past six months, or the number of cloud servers required to support a particular site over the past two years — and attempting to project that quantity into the future.

“That’s something that is very dear to Amazon’s heart,” Smola says. “For anything that Amazon does, it’s really beneficial to have a good estimate of what our customers will expect from us ahead of time. Only by being able to do that will we be able to satisfy customers’ demands, be it for products or services.”

A sequence of basis time series, forecast into the near future and summed together to approximate a new time series.
The paper “Think Globally, Act Locally” examines data sets with many correlated time series, such as the demand curves for millions of products sold online. The researchers describe a method for constructing a much smaller set of “basis time series”; the time series for any given product can be approximated by a weighted sum of the bases.
Courtesy of the researchers

The basic mathematical framework for time series forecasting is a century old, but the scale of modern forecasting problems calls for new analytic techniques, Smola says.

“Problems are nowadays highly multivariate,” Smola says. “If you look at the many millions of products that we offer, you want to be able to predict fairly well what will sell, where and to whom.

“You need to make reasonable assumptions on how this very large problem can be decomposed into smaller, more tractable pieces. You make structural approximations, and sometimes those structural approximations are what leads to very different algorithms.

“So you might, for instance, have a global model, and then you have local models that address the specific items or address the specific sales. If you look at ‘Think Globally, Act Locally’” — a NeurIPS paper whose first author is Rajat Sen, an applied scientist in the Amazon Search group — “it’s already in the title. Or look at ‘High-Dimensional Multivariate Forecasting with Low-Rank Gaussian Copula Processes’. In this case, you have a global structure, but it’s only in a small subspace where interesting things happen.”

Side-by-side images depict correlations between taxi traffic at different points in Manhattan at different times of day
The paper "High-Dimensional Multivariate Forecasting with Low-Rank Gaussian Copula Processes" describes a method for predicting correlations among many parallel time series. In one example, the researchers forecast correlations between the taxi traffic at different points in New York City at different times of day. Red lines indicate strong correlations; blue lines indicate strong negative correlations. Weekend midday traffic patterns (left) show negative correlations between locations near the Empire State Building, suggesting that taxis tend to prefer different routes depending on traffic conditions. Weekend evening traffic patterns show positive correlations between the vicinity of the Empire State Building and areas with high concentrations of hotels.
Courtesy of the researchers

An aspect of forecasting that has recently been drawing more attention, Smola says, is causality. Where traditional machine learning models merely infer statistical correlations between data points, “it is ultimately the causal relationship that matters,” Smola says.

“I think that causality is one of the most interesting conceptual developments affecting modern machine learning,” says Bernhard Schölkopf, like Smola a vice president and distinguished scientist in Amazon Web Services. “This is the main topic that I have been interested in for the last decade.”

Two of Schölkopf’s NeurIPS papers — “Perceiving the Arrow of Time in Autoregressive Motion” and “Selecting Causal Brain Features with a Single Conditional Independence Test per Feature” — address questions of causality, as does “Causal Regularization”, a paper by Dominik Janzing, a senior research scientist in Smola’s group.

“Normal machine learning builds on correlations of other statistical dependences,” Schölkopf explains. “This is fine as long as the source of the data doesn't change. For example, if in the training set of an image recognition system, all cows are standing on green pasture, then it is fine for an ML system to use the green as a useful feature in recognizing cows, as long as the test set looks the same. If in the test set, the cows are standing on the beach, then such a purely statistical system can fail.

“More generally: causal learning and inference attempts to understand how systems respond to interventions and other changes, and not just how to predict data that looks more or less the same as the training data.”

2. Bandit problems

The second major theme that Smola discerns in Amazon scientists’ NeurIPS papers is a concern with bandit problems, a phrase that shows up in the titles of Amazon papers such as “MaxGap Bandit: Adaptive Algorithms for Approximate Ranking” and “Low-Rank Bandit Methods for High-Dimensional Dynamic Pricing”. Bandit problems take their name from one-armed bandits, or slot machines.

“It used to be that those bandits were all mechanical, so there would be slight variations between them, and some would have maybe a slightly a higher return than others,” Smola explains. “I walk into a den of iniquity, and I want to find the one-armed bandit where I will lose the least money or maybe make some money. And the only feedback I have is that I pull arms, and I get money or lose money. These are very unreliable, noisy events.”

Bandit problems present what’s known as an explore-exploit trade-off. The gambler must simultaneously explore the environment — determine which machines pay out the most — and exploit the resulting knowledge — concentrate as much money as possible on the high-return machines. Early work on bandit problems concerned identifying the high-return machines with minimal outlays.

“That problem was solved about 20 years ago,” Smola says. “What hasn’t been solved — and this is where things get a lot more interesting — is once you start adding context. Imagine that I get to show you various results as you’re searching for your next ugly Christmas sweater. The unfortunate thing is that the creativity of sweater designers is larger than what you can fit on a page. Now the context is essentially, what time, where from, which user, all those things. We want to find and recommend the ugly Christmas sweater that works specifically for you. This is an example where context is immediately relevant.”

It’s really beneficial to have a good estimate of what our customers will expect from us ahead of time. Only by being able to do that will we be able to satisfy customers’ demands.
Alex Smola, VP and distinguished scientist, Amazon

In the bandit-problem framework, in other words, the high-payout machines change with every new interaction. But there may be external signals that indicate how they’re changing.

Distributed computing, which is inescapable for today’s large websites, changes the structure of the bandit problem, too.

“Say you go to a restaurant, and the cook wants to improve the menu,” Smola says. “You can try out lots of new menu items, and that’s a good way to improve the menu overall. But if you start offering a lot of undercooked dishes because you’re experimenting, then at some point your loyal customers will stay away.

“Now imagine you have 100 restaurants, and they all do the same thing at the same time. They can’t necessarily communicate at the per-second level; maybe every day or every week they chat with each other. Now this entire exploration problem becomes a little more challenging, because if two restaurants try out the same undercooked dish, you make the customer less happy than you could have.

“So how does this map back into Amazon land? Well, if you have many servers doing this recommendation, the explore-exploit trade-off might be too aggressive if every one of them works on their own.”

3. Optimization

Finally, Smola says, “There is a third category of results that has to do with making algorithms faster. If you look at ‘Primal-Dual Block Frank-Wolfe’, ‘Communication-Efficient Distributed SGD with Sketching’, ‘Qsparse-Local-SGD’ — those are the workhorses that run underneath all of this. Making them more efficient is obviously something that we care about, so we can respond to customer requests faster, train algorithms faster.”

Bird’s-eye view

NeurIPS is a huge conference, with more than 1,400 accepted papers that cover a bewildering variety of topics. Beyond the Amazon papers, Caltech professor and Amazon fellow Pietro Perona identifies three research areas as growing in popularity.

“One is understanding how deep networks work, so that we can better design architectures and optimization algorithms to train models,” Perona says. “Another is low-shot learning. Machines are still much less efficient than humans at learning, in that they need more training examples to achieve the same performance. And finally, AI and society — identifying opportunities for social good, sustainable development, and the like.”

NeurIPS is being held this year at the Vancouver Convention Center, and the main conference runs from Dec. 8 to Dec. 12. The Women in Machine Learning Workshop, for which Amazon is a gold-level sponsor, takes place on Dec. 9; the Third Conversational AI workshop, whose organizers include Alexa AI principal scientist Dilek Hakkani-Tür, will be held on Dec. 14.

Amazon's involvement at NeurIPS

Paper and presentation schedule

Tuesday, 12/10 | 10:45-12:45pm | East Exhibition Hall B&C

A Meta-MDP Approach to Exploration for Lifelong Reinforcement Learning | #192
Francisco Garcia (UMass Amherst/Amazon) · Philip Thomas (UMass Amherst)

Blocking Bandits | #17
Soumya Basu (UT Austin) · Rajat Sen (UT Austin/Amazon) · Sujay Sanghavi (UT Austin/Amazon) · Sanjay Shakkottai (UT Austin)

Causal Regularization | #180
Dominik Janzing (Amazon)

Communication-Efficient Distributed SGD with Sketching | #81
Nikita Ivkin (Amazon) · Daniel Rothchild (University of California, Berkeley) · Md Enayat Ullah (Johns Hopkins University) · Vladimir Braverman (Johns Hopkins University) · Ion Stoica (UC Berkeley) · Raman Arora (Johns Hopkins University)

Learning Distributions Generated by One-Layer ReLU Networks | #49
Shanshan Wu (UT Austin) ·Alexandros G. Dimakis (UT Austin) · Sujay Sanghavi (UT Austin/Amazon)

Tuesday, 12/10 | 5:30-7:30pm | East Exhibition Hall B&C

Efficient Communication in Multi-Agent Reinforcement Learning via Variance Based Control | #195
Sai Qian Zhang (Harvard University) · Qi Zhang (Amazon) · Jieyu Lin (University of Toronto)

Extreme Classification in Log Memory using Count-Min Sketch: A Case Study of Amazon Search with 50M Products | #37
Tharun Kumar Reddy Medini (Rice University) · Qixuan Huang (Rice University) · Yiqiu Wang (Massachusetts Institute of Technology) · Vijai Mohan (Amazon) · Anshumali Shrivastava (Rice University/Amazon)

Iterative Least Trimmed Squares for Mixed Linear Regression | #50
Yanyao Shen (UT Austin) · Sujay Sanghavi (UT Austin/Amazon)

Meta-Surrogate Benchmarking for Hyperparameter Optimization | #6
Aaron Klein (Amazon) · Zhenwen Dai (Spotify) · Frank Hutter (University of Freiburg) · Neil Lawrence (University of Cambridge) · Javier Gonzalez (Amazon)

Qsparse-local-SGD: Distributed SGD with Quantization, Sparsification and Local Computations | #32
Debraj Basu (Adobe) · Deepesh Data (UCLA) · Can Karakus (Amazon) · Suhas Diggavi (UCLA)

Selecting Causal Brain Features with a Single Conditional Independence Test per Feature | #139
Atalanti Mastakouri (Max Planck Institute for Intelligent Systems) · Bernhard Schölkopf (MPI for Intelligent Systems/Amazon) · Dominik Janzing (Amazon)

Wednesday, 12/11 | 10:45-12:45pm | East Exhibition Hall B&C

On Single Source Robustness in Deep Fusion Models | #93
Taewan Kim (Amazon) · Joydeep Ghosh (UT Austin)

Perceiving the Arrow of Time in Autoregressive Motion | #155
Kristof Meding (University Tübingen) · Dominik Janzing (Amazon) · Bernhard Schölkopf (MPI for Intelligent Systems/Amazon) · Felix A. Wichmann (University of Tübingen)

Wednesday, 12/11 | 5:00-7:00pm | East Exhibition Hall B&C

Compositional De-Attention Networks | #127
Yi Tay (Nanyang Technological University) · Anh Tuan Luu (MIT) · Aston Zhang (Amazon) · Shuohang Wang (Singapore Management University) · Siu Cheung Hui (Nanyang Technological University)

Low-Rank Bandit Methods for High-Dimensional Dynamic Pricing | #3
Jonas Mueller (Amazon) · Vasilis Syrgkanis (Microsoft Research) · Matt Taddy (Amazon)

MaxGap Bandit: Adaptive Algorithms for Approximate Ranking | #4
Sumeet Katariya (Amazon/University of Wisconsin-Madison) · Ardhendu Tripathy (UW Madison) · Robert Nowak (UW Madison)

Primal-Dual Block Generalized Frank-Wolfe | #165
Qi Lei (UT Austin) · Jiacheng Zhuo (UT Austin) · Constantine Caramanis (UT Austin) · Inderjit S Dhillon (Amazon/UT Austin) · Alexandros Dimakis (UT Austin)

Towards Optimal Off-Policy Evaluation for Reinforcement Learning with Marginalized Importance Sampling | #208
Tengyang Xie (University of Illinois at Urbana-Champaign) · Yifei Ma (Amazon) · Yu-Xiang Wang (UC Santa Barbara)

Thursday, 12/12 | 10:45-12:45pm | East Exhibition Hall B&C

AutoAssist: A Framework to Accelerate Training of Deep Neural Networks | #155
Jiong Zhang (UT Austin) · Hsiang-Fu Yu (Amazon) · Inderjit S Dhillon (UT Austin/Amazon)

Exponentially Convergent Stochastic k-PCA without Variance Reduction | #200 (oral, 10:05-10:20 W Ballroom C)
Cheng Tang (Amazon)

Failing Loudly: An Empirical Study of Methods for Detecting Dataset Shift | #54
Stephan Rabanser (Technical University of Munich/Amazon) · Stephan Günnemann (Technical University of Munich) · Zachary Lipton (Carnegie Mellon University/Amazon)

High-Dimensional Multivariate Forecasting with Low-Rank Gaussian Copula Processes | #107
David Salinas (Naverlabs) · Michael Bohlke-Schneider (Amazon) · Laurent Callot (Amazon) · Jan Gasthaus (Amazon) · Roberto Medico (Ghent University)

Learning Search Spaces for Bayesian Optimization: Another View of Hyperparameter Transfer Learning | #30
Valerio Perrone (Amazon) · Huibin Shen (Amazon) · Matthias Seeger (Amazon) · Cedric Archambeau (Amazon) · Rodolphe Jenatton (Amazon)

Mo’States Mo’Problems: Emergency Stop Mechanisms from Observation | #227
Samuel Ainsworth (University of Washington) · Matt Barnes (University of Washington) · Siddhartha Srinivasa (University of Washington/Amazon)

Think Globally, Act Locally: A Deep Neural Network Approach to High-Dimensional Time Series Forecasting | #113
Rajat Sen (Amazon) · Hsiang-Fu Yu (Amazon) · Inderjit S Dhillon (UT Austin/Amazon)

Thursday, 12/12 | 5:00-7:00pm | East Exhibition Hall B&C

Dynamic Local Regret for Non-Convex Online Forecasting | #20
Sergul Aydore (Stevens Institute of Technology) · Tianhao Zhu (Stevens Institute of Technology) · Dean Foster (Amazon)

Interaction Hard Thresholding: Consistent Sparse Quadratic Regression in Sub-quadratic Time and Space | #47
Suo Yang (UT Austin), Yanyao Shen (UT Austin), Sujay Sanghavi (UT Austin/Amazon)

Inverting Deep Generative Models, One Layer at a Time |#48
Qi Lei (University of Texas at Austin) · Ajil Jalal (UT Austin) · Inderjit S Dhillon (UT Austin/Amazon) · Alexandros Dimakis (UT Austin)

Provable Non-linear Inductive Matrix Completion| #215
Kai Zhong (Amazon) · Zhao Song (UT Austin) · Prateek Jain (Microsoft Research) · Inderjit S Dhillon (UT Austin/Amazon)

Amazon researchers on NeurIPS committees and boards

  • Bernhard Schölkopf – Advisory Board
  • Michael I. Jordan – Advisory Board
  • Thorsten Joachims – senior area chair
  • Anshumali Shrivastava – area chair
  • Cedric Archambeau – area chair
  • Peter Gehler – area chair
  • Sujay Sanghavi – committee member

Workshops

Learning with Rich Experience: Integration of Learning Paradigms

Paper: "Meta-Q-Learning" | Rasool Fakoor, Pratik Chaudhari, Stefano Soatto, Alexander J. Smola

Human-Centric Machine Learning

Paper: "Learning Fair and Transferable Representations" | Luco Oneto, Michele Donini, Andreas Maurer, Massimiliano Pontil

Bayesian Deep Learning

Paper: "Online Bayesian Learning for E-Commerce Query Reformulation" | Gaurush Hiranandani, Sumeet Katariya, Nikhil Rao, Karthik Subbian

Meta-Learning

Paper: "Constrained Bayesian Optimization with Max-Value Entropy Search" | Valerio Perrone, Iaroslav Shcherbatyi, Rodolphe Jenatton, Cedric Archambeau, Matthias Seeger

Paper: "A Quantile-Based Approach to Hyperparameter Transfer Learning" | David Salinas, Huibin Shen, Valerio Perrone

Paper: "A Baseline for Few-Shot Image Classification" | Guneet Singh Dhillon, Pratik Chaudhari, Avinash Ravichandran, Stefano Soatto

Conversational AI

Organizer: Dilek Hakkani-Tür

Paper: "The Eighth Dialog System Technology Challenge" | Seokhwan Kim, Michel Galley, Chulaka Gunasekara, Sungjin Lee, Adam Atkinson, Baolin Peng, Hannes Schulz, Jianfeng Gao, Jinchao Li, Mahmoud Adada, Minlie Huang, Luis Lastras, Jonathan K. Kummerfeld, Walter S. Lasecki, Chiori Hori, Anoop Cherian, Tim K. Marks, Abhinav Rastogi, Xiaoxue Zang, Srinivas Sunkara, Raghav Gupta

Paper: “Just Ask: An Interactive Learning Framework for Vision and Language Navigation” | Ta-Chung Chi, Minmin Shen, Mihail Eric, Seokhwan Kim, Dilek Hakkani-Tur

Paper: “MA-DST: Multi-Attention-Based Scalable Dialog State Tracking” | Adarsh Kumar, Peter Ku, Anuj Kumar Goyal, Angeliki Metallinou, Dilek Hakkani-Tür

Paper: “Investigation of Error Simulation Techniques for Learning Dialog Policies for Conversational Error Recovery” | Maryam Fazel-Zarandi, Longshaokan Wang, Aditya Tiwari, Spyros Matsoukas

Paper: “Towards Personalized Dialog Policies for Conversational Skill Discovery”| Maryam Fazel-Zarandi, Sampat Biswas, Ryan Summers, Ahmed Elmalt, Andy McCraw, Michael McPhillips, John Peach

Paper: “Conversation Quality Evaluation via User Satisfaction Estimation” | Praveen Kumar Bodigutla, Spyros Matsoukas, Lazaros Polymenakos

Paper: “Multi-domain Dialogue State Tracking as Dynamic Knowledge Graph Enhanced Question Answering” | Li Zhou, Kevin Small

Science Meets Engineering of Deep Learning

Paper: "X-BERT: eXtreme Multi-label Text Classification using Bidirectional Encoder from Transformers" Wei-Cheng Chang, Hsiang-Fu Yu, Kai Zhong, Yiming Yang, Inderjit S. Dhillon

Machine Learning with Guarantees

Organizers: Ben London, Thorsten Joachims
Program Committee: Kevin Small, Shiva Kasiviswanathan, Ted Sandler

MLSys: Workshop on Systems for ML

Paper: "Block-Distributed Gradient Boosted Trees" | Theodore Vasiloudis, Hyunsu Cho, Henrik Boström

Women in Machine Learning

Gold sponsor: Amazon

Research areas

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Amazon Advertising is one of Amazon's fastest growing and most profitable businesses, responsible for defining and delivering a collection of advertising products that drive discovery and sales. Our products are strategically important to our businesses driving long term growth. We deliver billions of ad impressions and millions of clicks and break fresh ground in product and technical innovations every day! Advertiser Growth Engine (AGE) team owns and builds services and applications across Amazon World-Wide Advertising that make advertising across multi-marketplaces as easy as flipping on a switch. We are focused on: (1) expanding Amazon Ads advertiser base, and (2) eliminating localization, operational, and marketplace knowledge gap barrier for Advertisers who advertise across multiple marketplaces. Our products and solutions are strategically important to enable our Retail and Marketplace businesses to drive long-term growth globally. We're looking for an experienced Applied Scientist with exceptional technical, analytical, and innovative capabilities to research, design, and create elegant machine learning solutions. The solutions will help our advertisers with multi-media and multi-lingual advertising offerings. You will use ideas from various domains of machine learning, including supervised and unsupervised methods, Deep Neural Networks, Natural Language Processing (NLP), and Computer Vision (CV) to build ML models that localizes multi-media advertising contents, including text, images and videos. You will also identify opportunities to leverage ML beyond localization, including, international expansion and global campaigns. Your work will directly impact our customers in the form of products and services used directly by our advertisers as well as our third-party integrators. As an Applied Scientist on this team, you will: - Build and deliver end-to-end machine learning solutions; build ML models and perform data analysis to deliver scalable solutions to business problems. - Perform hands-on analysis and modeling with enormous data sets to develop insights that increase traffic monetization and merchandise sales without compromising shopper experience. - Work closely with software engineers on detailed requirements to productionize the ML models you build. - Run A/B experiments that affect hundreds of millions of customers, evaluate the impact of your optimizations and communicate your results to various business stakeholders. - Establish scalable, efficient, automated processes for large-scale data analysis, machine-learning model development, model validation and serving. - Research new innovate machine learning approaches. Why you will love this opportunity: Amazon is investing heavily in building a world-class advertising business. This team defines and delivers a collection of advertising products that drive discovery and sales. Our solutions generate billions in revenue and drive long-term growth for Amazon’s Retail and Marketplace businesses. We deliver billions of ad impressions, millions of clicks daily, and break fresh ground to create world-class products. We are a highly motivated, collaborative, and fun-loving team with an entrepreneurial spirit - with a broad mandate to experiment and innovate. Impact and Career Growth: You will invent new experiences and influence customer-facing shopping experiences to help suppliers grow their retail business and the auction dynamics that leverage native advertising; this is your opportunity to work within the fastest-growing businesses across all of Amazon! Define a long-term science vision for our advertising business, driven from our customers' needs, translating that direction into specific plans for research and applied scientists, as well as engineering and product teams. This role combines science leadership, organizational ability, technical strength, product focus, and business understanding. Team video https://youtu.be/zD_6Lzw8raE
US, NY, New York
We are seeking an Applied Scientist to lead the development of evaluation frameworks and data collection protocols for robotic capabilities. In this role, you will focus on designing how we measure, stress-test, and improve robot behavior across a wide range of real-world tasks. Your work will play a critical role in shaping how policies are validated and how high-quality datasets are generated to accelerate system performance. You will operate at the intersection of robotics, machine learning, and human-in-the-loop systems, building the infrastructure and methodologies that connect teleoperation, evaluation, and learning. This includes developing evaluation policies, defining task structures, and contributing to operator-facing interfaces that enable scalable and reliable data collection. The ideal candidate is highly experimental, systems-oriented, and comfortable working across software, robotics, and data pipelines, with a strong focus on turning ambiguous capability goals into measurable and actionable evaluation systems. Key job responsibilities - Design and implement evaluation frameworks to measure robot capabilities across structured tasks, edge cases, and real-world scenarios - Develop task definitions, success criteria, and benchmarking methodologies that enable consistent and reproducible evaluation of policies - Create and refine data collection protocols that generate high-quality, task-relevant datasets aligned with model development needs - Build and iterate on teleoperation workflows and operator interfaces to support efficient, reliable, and scalable data collection - Analyze evaluation results and collected data to identify performance gaps, failure modes, and opportunities for targeted data collection - Collaborate with engineering teams to integrate evaluation tooling, logging systems, and data pipelines into the broader robotics stack - Stay current with advances in robotics, evaluation methodologies, and human-in-the-loop learning to continuously improve internal approaches - Lead technical projects from conception through production deployment - Mentor junior scientists and engineers
IL, Tel Aviv
Are you a scientist interested in pushing the state of the art in Information Retrieval, Large Language Models and Recommendation Systems? Are you interested in innovating on behalf of millions of customers, helping them accomplish their every day goals? Do you wish you had access to large datasets and tremendous computational resources? Do you want to join a team of capable scientist and engineers, building the future of e-commerce? Answer yes to any of these questions, and you will be a great fit for our team at Amazon. Our team is part of Amazon’s Personalization organization, a high-performing group that leverages Amazon’s expertise in machine learning, generative AI, large-scale data systems, and user experience design to deliver the best shopping experiences for our customers. Our team is building next-generation personalization systems powered by Large Language Models. We are tackling novel research challenges to help customers discover products they'll love - at Amazon scale and latency requirements. We are a team uniquely placed within Amazon, to have a direct window of opportunity to influence how customers will think about their shopping journey in the future. As an Applied Science Manager, you will lead a team of scientists working at the frontier of LLM-based personalization. You will set the technical vision, drive the research agenda, and ensure your team delivers production-ready solutions. You will hire, mentor, and develop world-class scientists while fostering a culture of innovation and scientific rigor. You will partner closely with engineering and product teams to translate ambitious research into customer-facing impact, and represent your team's work to senior leadership. Please visit https://www.amazon.science for more information.
US, WA, Seattle
AWS Applied AI Solutions (AAIS) is building toward a future where every business innovates with Amazon AI teammates. To get there, we build AI solutions that improve human capabilities and transform entire business functions. We create end-to-end products that surprise and delight out-of-the-box, making complex things easy and hard things possible, with no cloud experience required. We start with customers who embrace the future and build bridges to meet the rest where they are. We pursue ambitious opportunities with conviction, and we are looking for builders who share that mindset. The Team Join the next science revolution at AWS Life Sciences Applied AI Solutions where you'll work alongside world-class scientists to build AI that transforms how therapeutics are discovered, developed, and brought to patients. We're out to revolutionize how medicines are discovered, developed, and brought to patients powered by a new generation of AI. Our team tackles some of the hardest open problems at the intersection of frontier AI and life sciences. We apply biological foundation models large language models and agentic reasoning systems to life sciences problems then put them into the hands of customers as applications and managed services they can fine-tune tailor and deploy on their own data. The science challenges are deep: how do you design agentic systems that reason correctly over complex biological regulatory and clinical logic? How do you enable customers to tailor foundation models to their proprietary data and get better outputs with less effort? How do you adapt models to reason faithfully in high-stakes scientific and regulatory domains? Today we're focused on two areas. In clinical trials we're building AI that automates and optimizes regulatory and clinical development workflows. In drug design our products (including Amazon Bio Discovery) accelerate discovery by giving bench scientists AI-guided protein engineering and antibody design capabilities. We combine frontier research with production-scale delivery to put breakthrough science into the hands of customers solving humanity's hardest problems. We value scientific rigor encourage publication and support conference participation. If you want to do research that ships this is the team. The Role We are seeking an Applied Scientist to build the models and methods behind our life sciences AI products with a primary focus on clinical trial operations and agentic reasoning. You will design train and evaluate systems that reason over complex clinical and operational logic and ship them into products customers use directly. You will work closely with senior and principal scientists on well-scoped research problems own your results end to end and see your work reach production. This role combines expertise in LLM reasoning and agentic AI with applied impact in life sciences. You will work on how large language models reason plan and act in complex scientific domains while applying domain knowledge to ensure models produce scientifically valid outputs. The problems span multiple fronts: • How do you build LLM-based agentic systems that correctly reason over clinical protocols regulatory standards and complex multi-step operational workflows? • How do you evaluate agent reliability and faithfulness rigorously enough to trust in high-stakes clinical settings? • How do you develop model customization methods (fine-tuning retrieval augmentation domain adaptation) that let customers get strong results from foundation models on their own data? You will focus on clinical trial operations (agentic automation structured reasoning evaluation domain adaptation) with opportunities to contribute across drug discovery (protein engineering antibody design) as the portfolio grows. You will own end-to-end scientific solutions from research through production and your work will directly shape the tools that scientists use daily. Key job responsibilities • Design train fine-tune and evaluate LLM-based agentic systems that reason over clinical protocols regulatory standards and operational workflows • Build rigorous evaluation harnesses and benchmarks to measure agent reliability faithfulness and failure modes in high-stakes domains • Develop model customization methods (fine-tuning RLHF retrieval augmentation domain adaptation) that help customers get better outputs on their own data with less effort • Contribute to graph-based and causal modeling approaches for clinical trial operations • Partner with Life Sciences domain experts product and engineering to translate scientific challenges into shipped capabilities • Own experiments end to end: problem framing implementation evaluation iteration and hand-off to production • Publish at top-tier venues where the work supports it • Contribute to drug discovery efforts (protein engineering antibody design) as opportunities arise A day in the life • Design and run an experiment to validate a new agentic reasoning or fine-tuning method then ship it as a capability customers can use • Diagnose why a model is failing on a new class of inputs and implement a fix to unblock a delivery milestone • Build or extend an evaluation benchmark to measure how faithfully an agent reasons over clinical logic • Meet with domain experts to scope what the next model release needs to do • Review results with a senior scientist sharpen the approach and get it over the finish line • Prototype a new idea that could become the next capability in the product About the team Amazon values diverse experiences. Even if you do not meet all of the preferred qualifications and skills listed in the job description, we encourage candidates to apply. If your career is just starting, hasn't followed a traditional path, or includes alternative experiences, don't let it stop you from applying. Amazon Web Services (AWS) is the world's most comprehensive and broadly adopted cloud platform. We pioneered cloud computing and never stopped innovating — that's why customers from the most successful startups to Global 500 companies trust our robust suite of products and services to power their businesses. We value work-life harmony. Achieving success at work should never come at the expense of sacrifices at home, which is why flexible work hours and arrangements are part of our culture. When we feel supported in the workplace and at home, there's nothing we can't achieve in the cloud. Here at AWS, it's in our nature to learn and be curious. Our employee-led affinity groups foster a culture of inclusion that empower us to be proud of our differences. Ongoing events and learning experiences, including our Conversations on Race and Ethnicity and AmazeCon conferences, inspire us to never stop embracing our uniqueness. We're continuously raising our performance bar as we strive to become Earth's Best Employer. That's why you'll find endless knowledge-sharing, mentorship and other career-advancing resources here to help you develop into a better-rounded professional.
BR, SP, Sao Paulo
Do you feel the challenge and the adrenaline kick when a huge data-set stares you in the face and you know that somewhere inside are hidden very important business insights that can fundamentally alter the way top business leaders think and act? Do you enjoy presenting strong data backed insights to business leaders; insights that can topple their long held beliefs and compel them to change their direction completely? If yes, then you are the one we are looking for. We are looking to invite passionate leaders, with expertise in generate power business insights from very large datasets, on a journey where the primary aim would be to enable needle moving business impacts through statistical analysis. We are looking for leaders who can envision the design and development of analytical infrastructure which can support strategic and tactical decision-making. Those who join this high visibility team would have to navigate through significant ambiguity in defining business problems and converting them to analytical problems. This role requires additional exposure and experience to Machine Learning. Key job responsibilities Use machine learning and analytical techniques to create scalable solutions for business problems • Analyze and extract relevant information from large amounts of Amazon’s historical business data to help automate and optimize key processes • Design, development, evaluate and deploy innovative and highly scalable ml models such as risk scorecards, income models, fraud models for predictive learning in credit risk applications • Research and implement novel machine learning and statistical approaches • Work closely with software engineering teams to drive real-time model implementations and new feature creations • Work closely with business owners and operations staff to optimize various business operations • Establish scalable, efficient, automated processes for large scale data analyses, model development, model validation and model implementation • Mentor other scientists and engineers in the use of ML techniques • Innovate with the latest GenAI technology to build highly automated solutions for efficient customer promotions • Design, develop and deploy end-to-end machine learning solutions in the Amazon production environment to delight Amazon customers • Collaborate with cross-functional teams to develop comprehensive ML/statistical models that can scale to millions of customers to multiple countries Understand the credit risk data and evaluate the best ml model/ solution for dynamic business problems. About the team Brazil Payments is part of the International Emerging Stores Payments team and focuses on supporting the launch of new payment and financial products to our customers in Brazil.
BR, SP, Sao Paulo
Do you feel the challenge and the adrenaline kick when a huge data-set stares you in the face and you know that somewhere inside are hidden very important business insights that can fundamentally alter the way top business leaders think and act? Do you enjoy presenting strong data backed insights to business leaders; insights that can topple their long held beliefs and compel them to change their direction completely? If yes, then you are the one we are looking for. We are looking to invite passionate leaders, with expertise in generate power business insights from very large datasets, on a journey where the primary aim would be to enable needle moving business impacts through statistical analysis. We are looking for leaders who can envision the design and development of analytical infrastructure which can support strategic and tactical decision-making. Those who join this high visibility team would have to navigate through significant ambiguity in defining business problems and converting them to analytical problems. This role requires additional exposure and experience to Machine Learning. Key job responsibilities • Use machine learning and analytical techniques to create scalable solutions for business problems • Analyze and extract relevant information from large amounts of Amazon’s historical business data to help automate and optimize key processes • Design, development, evaluate and deploy innovative and highly scalable models for predictive learning • Research and implement novel machine learning and statistical approaches • Work closely with software engineering teams to drive real-time model implementations and new feature creations • Work closely with business owners and operations staff to optimize various business operations • Establish scalable, efficient, automated processes for large scale data analyses, model development, model validation and model implementation • Mentor other scientists and engineers in the use of ML techniques • Innovate with the latest GenAI technology to build highly automated solutions for efficient customer promotions • Design, develop and deploy end-to-end machine learning solutions in the Amazon production environment to delight Amazon customers • Collaborate with cross-functional teams to develop comprehensive ML/statistical models that can scale to millions of customers to multiple countries About the team Brazil Payments is part of the International Emerging Stores Payments team and focuses on supporting the launch of new payment and financial products to our customers in Brazil.
BR, SP, Sao Paulo
Do you feel the challenge and the adrenaline kick when a huge data-set stares you in the face and you know that somewhere inside are hidden very important business insights that can fundamentally alter the way top business leaders think and act? Do you enjoy presenting strong data backed insights to business leaders; insights that can topple their long held beliefs and compel them to change their direction completely? If yes, then you are the one we are looking for. We are looking to invite passionate leaders, with expertise in generate power business insights from very large datasets, on a journey where the primary aim would be to enable needle moving business impacts through statistical analysis. We are looking for leaders who can envision the design and development of analytical infrastructure which can support strategic and tactical decision-making. Those who join this high visibility team would have to navigate through significant ambiguity in defining business problems and converting them to analytical problems. This role requires additional exposure and experience to Machine Learning. Key job responsibilities Use machine learning and analytical techniques to create scalable solutions for business problems • Analyze and extract relevant information from large amounts of Amazon’s historical business data to help automate and optimize key processes • Design, development, evaluate and deploy innovative and highly scalable ml models such as risk scorecards, income models, fraud models for predictive learning in credit risk applications • Research and implement novel machine learning and statistical approaches • Work closely with software engineering teams to drive real-time model implementations and new feature creations • Work closely with business owners and operations staff to optimize various business operations • Establish scalable, efficient, automated processes for large scale data analyses, model development, model validation and model implementation • Mentor other scientists and engineers in the use of ML techniques • Innovate with the latest GenAI technology to build highly automated solutions for efficient customer promotions • Design, develop and deploy end-to-end machine learning solutions in the Amazon production environment to delight Amazon customers • Collaborate with cross-functional teams to develop comprehensive ML/statistical models that can scale to millions of customers to multiple countries Understand the credit risk data and evaluate the best ml model/ solution for dynamic business problems. About the team Brazil Payments is part of the International Emerging Stores Payments team and focuses on supporting the launch of new payment and financial products to our customers in Brazil.